EphB4 Products

Antibodies
EphB4 Antibody
EphB4 Antibody
AF446
Species: Mu
Applications: WB, Flow, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
EphB4 Antibody [Unconjugated] ...
EphB4 Antibody [Unconjugated]
AF3038
Species: Hu
Applications: WB, Simple Western, Flow, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Lysates
EphB4 Overexpression Lysate ( ...
EphB4 Overexpression Lysate (Native)
NBL1-10293
Applications: WB
Proteins
EphB4 Recombinant Protein
EphB4 Recombinant Protein
NBP2-52387
Species: Mu
Applications: PAGE
RNAi
EphB4 RNAi
EphB4 RNAi
H00002050-R04
Species: Hu

Description

EphB4, also known as Htk, Myk1, Tyro11, and Mdk2, is a member of the Eph receptor family, which binds of the ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region contains juxtamembrane motif with two tyrosines, which are the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxyl terminus, which includes one conserved tyrosine. Ligand recognition and binding leads to activation of intrinsic kinase activity. Only membrane-bound or Fc-clustered ligands have been shown to activate the receptor in vitro. Soluble monomeric ligands can bind the receptor, but do not induce receptor autophosphorylation and activation. The Eph receptors and ephrin ligands display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands.Ephs and ephrins play a significant role in angiogenesis.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 2050
Alternate Names
  • EC 2.7.10
  • EphB4
  • soluble EPHB4 variant 3
  • MYK1
  • soluble EPHB4 variant 2
  • EC 2.7.10.1
  • soluble EPHB4 variant 1
  • TYRO11
  • hepatoma transmembrane kinase
  • Tyrosine-protein kinase TYRO11
  • ephrin type-B receptor 4
  • Tyrosine-protein kinase receptor HTK
  • HTKephrin receptor EphB4
  • Tyro11
  • EPH receptor B4

Research Areas for EphB4

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase

PTMs for EphB4

Learn more about PTMs related to EphB4.

Phosphorylation
Methylation
Cleavage
Reduction
Dephosphorylation

Bioinformatics Tool for EphB4

Discover related pathways, diseases and genes to EphB4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related EphB4 Blog Posts

Check out the latest blog posts on EphB4.
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