WB, Flow, IHC, CyTOF-readyHost:
WB, Simple Western, Flow, IHC, CyTOF-ready, KOHost:
Applications: WB, Flow, CyTOF-ready
Host: Rat Monoclonal
EphB4, also known as Htk, Myk1, Tyro11, and Mdk2, is a member of the Eph receptor family, which binds of the ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region contains juxtamembrane motif with two tyrosines, which are the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxyl terminus, which includes one conserved tyrosine. Ligand recognition and binding leads to activation of intrinsic kinase activity. Only membrane-bound or Fc-clustered ligands have been shown to activate the receptor in vitro. Soluble monomeric ligands can bind the receptor, but do not induce receptor autophosphorylation and activation. The Eph receptors and ephrin ligands display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands.Ephs and ephrins play a significant role in angiogenesis.
|Product By Gene ID
- EC 2.7.10
- soluble EPHB4 variant 3
- soluble EPHB4 variant 2
- EC 22.214.171.124
- soluble EPHB4 variant 1
- hepatoma transmembrane kinase
- Tyrosine-protein kinase TYRO11
- ephrin type-B receptor 4
- Tyrosine-protein kinase receptor HTK
- HTKephrin receptor EphB4
- EPH receptor B4
Research Areas for EphB4
Find related products by research area and learn more about each of the different research areas below.Protein Kinase
Bioinformatics Tool for EphB4
Discover related pathways, diseases and genes to EphB4. Need help? Read the Bioinformatics Tool Guide
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Related EphB4 Blog Posts
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