Human IL-17A/F Heterodimer DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-17A/F Heterodimer DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-17A/F Heterodimer DuoSet ELISA, 15 Plate

• CTLA8
• CTLA8cytotoxic T-lymphocyte-associated serine esterase 8
• Cytotoxic T-lymphocyte-associated antigen 8
• Cytotoxic T-Lymphocyte-Associated Protein 8
• IL17
• IL-17
• IL-17A
• IL-17A/F Heterodimer
• interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
• interleukin 17A
• interleukin-17A

Background

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Publications for IL-17A/F Heterodimer (DY5194)(8)

Publications using DY5194

• H Wang, Y Li, Z Yue, Y Liu, Q Chen, D Hu, J Han Adipose-Derived Stem Cell Exosomes Inhibit Hypertrophic Scaring Formation by Regulating Th17/Treg Cell Balance BioMed Research International, 2022-10-12;2022(0):9899135. 2022-10-12 [PMID: 36277890] (Human)
• B Jung, G Ferrer, PY Chiu, R Aslam, A Ng, F Palacios, M Wysota, M Cardillo, JE Kolitz, SL Allen, JC Barrientos, KR Rai, N Chiorazzi, B Sherry Activated CLL cells regulate IL17F producing Th17 cells in miR155 dependent and outcome specific manners JCI Insight, 2022-06-22;0(0):. 2022-06-22 [PMID: 35511436] (Human)
• A Tosi, L Nardinocch, ML Carbone, L Capriotti, E Pagani, S Mastroeni, C Fortes, F Scopelliti, C Cattani, F Passarelli, A Rosato, S D'Atri, CM Failla, A Cavani Reduced Interleukin-17-Expressing Cells in Cutaneous Melanoma Biomedicines, 2021-12-16;9(12):. 2021-12-16 [PMID: 34944746] (Human)
• N Yao, T Tretter, P Kvacskay, W Merkt, N Blank, HM Lorenz, LO Tykocinski Targeting of Janus Kinases Limits Pro-Inflammatory but Also Immunosuppressive Circuits in the Crosstalk between Synovial Fibroblasts and Lymphocytes Biomedicines, 2021-10-08;9(10):. 2021-10-08 [PMID: 34680530] (Human)
• KH Liang, MW Lai, YH Lin, YD Chu, CL Lin, WR Lin, YH Huang, TH Wang, RN Chien, TH Hu, CT Yeh Plasma interleukin-17 and alpha-fetoprotein combination effectively predicts imminent hepatocellular carcinoma occurrence in liver cirrhotic patients BMC gastroenterology, 2021-04-17;21(1):177. 2021-04-17 [PMID: 33865328] (Human)
• R Gramlich, E Aliahmadi, M Peiser In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists Int J Mol Sci, 2019-03-19;20(6):. 2019-03-19 [PMID: 30893757] (Human)
• T Haruna, S Kariya, T Fujiwara, T Higaki, S Makihara, K Kanai, R Fujiwara, S Iwasaki, Y Noguchi, K Nishizaki, M Okano Association between impaired IL-10 production following exposure to Staphylococcus aureus enterotoxin B and disease severity in eosinophilic chronic rhinosinusitis Allergol Int, 2018-03-23;0(0):. 2018-03-23 [PMID: 29580813] (Human)
• Camargo J, Bhimji A, Kumar D, Kaul R, Pavan R, Schuh A, Seftel M, Lipton J, Gupta V, Humar A, Husain S Impaired T cell responsiveness to interleukin-6 in hematological patients with invasive aspergillosis. PLoS ONE, 2015-04-02;10(4):e0123171. 2015-04-02 [PMID: 25835547] (Human)

FAQs for IL-17A/F Heterodimer (DY5194). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.