Human IL-17 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human IL-17 Quantikine ELISA Kit Summary

• Background: The Quantikine Human IL-17 Immunoassay is a 4.5 hour solid phase ELISA designed to measure human IL-17 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-17 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human IL-17 accurately. Results obtained using natural human IL-17 sh...owed linear curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-17.
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• Additional Information: Quantikine Quickit version available - results in 90 minutes (QK317).
• Specificity: Natural and recombinant human IL-17
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL17A

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 degreesC. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-17 Quantikine ELISA Kit

• CTLA8
• CTLA-8
• CTLA8cytotoxic T-lymphocyte-associated serine esterase 8
• Cytotoxic T-lymphocyte-associated antigen 8
• IL17
• IL-17
• IL17A
• IL-17A
• IL-17Acytotoxic T-lymphocyte-associated protein 8
• IL-17CTLA-8
• IL17interleukin-17A
• interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
• interleukin 17A

Background

Human Interleukin 17 (IL-17), also known as IL-17A and CTLA-8, is a 15-20 kDa, variably glycosylated polypeptide that belongs to the IL-17 family of cytokines (1-5). Its alternate name, CTLA-8, originated from rodent studies where an activated hybridoma was created from the fusion of a mouse cytotoxic and a rat T cell lymphoma cell line. The molecule of interest in this study was assumed to have come from the mouse cytotoxic lymphocyte cell (thus the CTL designation), whereas, in fact, it was a rat lymphocyte molecule. Human IL-17/17A is synthesized as a 155 amino acid (aa) precursor that contains a 23 aa signal sequence and a 133 aa mature region that possesses a cysteine-knot fold (4-6). In both human and mouse, there is one conserved N-linked glycosylation site that likely contributes 5 kDa to its native molecular weight. IL-17A forms both a 32-38 kDa disulfide-linked homodimer, and a 40-45 kDa covalent heterodimer with IL-17F (7-9). Most secreted IL-17A is in the form of the IL-17A:F heterodimer, however, the IL-17A:A homodimer is the most bioactive of the two forms (8). Mature human IL-17A is 61%, 74%, and 99% aa identical to mouse, porcine, and chimpanzee IL-17A, respectively (10-12). Mammalian cells known to produce IL-17 are the CD4 + Th17 T cells, Paneth cells, GR1 + CD11b + myeloid suppressor cells, CD27 - gamma δ T cells, CD1 + NK1.1 - iNKT cells, and CD3 - CD4 + LTi-like cells (9, 13-17). A high affinity receptor for human IL-17 has been reported, and appears to be a heteromultimer of IL-17RA and IL-17RC, likely in a 2:1 ratio (1, 18). IL-17RA is a 130 kDa, type I transmembrane glycoprotein that bears no resemblance to members of the cytokine, TNF or immunoglobulin receptor superfamily (2, 10, 15). IL-17RC is also a type I transmembrane protein, approximately 90-95 kDa in size, that shares less than 30% aa identity with IL-17RA (19, 20). Both receptors are needed for IL-17A and IL-17A:F activity. The two receptors appear to form a functional association following ligand binding to IL-17RA (1, 21, 22). IL-17 is best known for its participation in the recruitment and survival of neutrophils (14, 15, 23, 24, 25). Its induction was initially described to be the result of antigen stimulation of dendritic cells, resulting in IL-23 secretion. In a T cell receptor-independent event, IL-23 induces T cell production of IL-17 (14). Once secreted, IL-17 in the bone marrow would seem to induce stromal/fibroblast expression of both G-CSF and stem cell factor (membrane form), an effect that increases polymorphonuclear neutrophils (PMN) differentiation and production. IL-17 may complement this by directly blocking neutrophil apoptosis, promoting greater circulating PMN numbers (23). In the tissues, IL-17 would also seem to promote neutrophil extravasation, principally through its effects on macrophages and endothelial cells (EC). On macrophages, IL-17 induces TNF-alpha , IL-1b and IL-6 production (26). TNF-alpha and IL-1b then act on local ECs to induce G-CSF secretion, an effect that is potentiated by IL-17 (27). IL-17 further contributes to PMN influx by inducing EC CXC chemokine release and NO production, which may increase vascular permeability (14, 28). IL-17 effects are not limited to inflammation. In synovial joints, IL-17 upregulates RANKL expression on osteoblasts. This provides a stimulus for osteoclast formation and subsequent bone resorption (24). In conjunction with IL-4 and CD40L, IL-17A also promotes the generation of IgE secreting cells (29). And in white fat, IL-17A inhibits adipocyte differentiation from preadipocytes, and impairs glucose uptake by mature adipocytes (30).

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-17/IL-17A (D1700)(97)

Publications using D1700

• Karched, M;Alkandari, S; Differential Proteomic Analysis of Extracellular Vesicles Produced by Granulicatella adiacens in Biofilm vs. Planktonic Lifestyle Dentistry journal 2025-11-26 [PMID: 41440315] (Human)
• Arita, K;Tao, H;Crowe, P;Thacher, S;Otake, S;Kobayashi, K;Ebihara, S;Okamoto, Y;Katsuda, Y;Yamaguchi, T;Matsushita, M; Pharmacological Properties of JTE-151; A Novel Orally Available ROR? Antagonist That Suppresses Th17 Cell-Related Responses <i>in Vitro</i> and <i>in Vivo</i> Biological and Pharmaceutical Bulletin 2024-12-12 [PMID: 39675971] (Human)
• Karwaciak, I;Pastwi?ska, J;Sa?kowska, A;Bachorz, RA;Ratajewski, M; Evaluation of the Activity of Cardiac Glycosides on ROR? and ROR?T Nuclear Receptors Archives of biochemistry and biophysics 2024-07-04 [PMID: 38971421] (Human)
• Kutuk, MO;Tufan, AE;Kilicaslan, F;Gokcen, C;Aksu, GG;Yektas, C;Kandemir, H;Celik, F;Mutluer, T;Buber, A;Karadag, M;Coban, N;Coskun, S;Hangul, Z;Altintas, E;Acikbas, U;Giray, A;Aka, Y;Basturk, B;Kutuk, O; Cytokine expression profiles in children and adolescents with tic disorders Scientific reports 2024-07-02 [PMID: 38956051] (Human)
• Scovino, AM;Dahab, EC;Diniz-Lima, I;de Senna Silveira, E;Barroso, SPC;Cardoso, KM;Nico, D;Makhoul, GJ;da Silva-Junior, EB;Freire-de-Lima, CG;Freire-de-Lima, L;Fonseca, LMD;Valente, N;Nacife, V;Machado, A;Araújo, M;Vieira, GF;Pauvolid-Corrêa, A;Siqueira, M;Morrot, A; A Comparative Analysis of Innate Immune Responses and the Structural Characterization of Spike from SARS-CoV-2 Gamma Variants and Subvariants Microorganisms 2024-04-02 [PMID: 38674664] (Human)
• CV Gonçalves, IS Ribeiro, MPL Galantini, IPR Muniz, PHB Lima, GS Santos, RAA da Silva Inflammaging and body composition: New insights in diabetic and hypertensive elderly men Experimental gerontology, 2022-10-28;170(0):112005. 2022-10-28 [PMID: 36341786] (Human)
• J Milosevic, M Jurisevic, V Grbovic, I Jovanovic, N Gajovic, A Jurisic-Sk Potential Protective Role of Galectin-3 in Patients with Gonarthrosis and Diabetes Mellitus: A Cross-Sectional Study International Journal of Environmental Research and Public Health, 2022-09-13;19(18):. 2022-09-13 [PMID: 36141752] (Human)
• Q Su, L Zhang, Z Qi, B Huang The Mechanism of Inflammatory Factors and Soluble Vascular Cell Adhesion Molecule-1 Regulated by Nuclear Transcription Factor NF-kappaB in Unstable Angina Pectoris Journal of Immunology Research, 2022-07-30;2022(0):6137219. 2022-07-30 [PMID: 35942210] (Human)
• MPL Galantini, IS Ribeiro, CV Gonçalves, IPR Muniz, PHB Lima, GS Santos, RAA da Silva The sweet fuel of inflammation: New perspectives on the complex web that interconnects diabetes Experimental gerontology, 2022-07-30;167(0):111905. 2022-07-30 [PMID: 35918042] (Human)
• S Luo, R Wu, Q Li, G Zhang Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus Journal of Immunology Research, 2022-05-10;2022(0):4053038. 2022-05-10 [PMID: 35592687] (Human)
• U Förster-Ru, AJ Szczepek, G Pierchalla, JW Fluhr, M Artuc, T Zuberbier, C Bachert, H Olze Chemokine Expression-Based Endotype Clustering of Chronic Rhinosinusitis Journal of personalized medicine, 2022-04-18;12(4):. 2022-04-18 [PMID: 35455762] (Human)
• J Pastwi?ska, K Kara?, A Sa?kowska, I Karwaciak, K Cha?a?kiew, BA Wojtczak, RA Bachorz, M Ratajewski Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORgammaT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity International Journal of Molecular Sciences, 2022-02-08;23(3):. 2022-02-08 [PMID: 35163824] (Human)
• WS Khalaf, MRA Mahmoud, WF Elkhatib, HR Hashem, WE Soliman Phenotypic characterization of NKT-like cells and evaluation of specifically related cytokines for the prediction of unexplained recurrent miscarriage Heliyon, 2021-11-16;7(11):e08409. 2021-11-16 [PMID: 34849421] (Human)
• LA Lucaciu, M Ilie?, ?C Vesa, R Seicean, S Din, CA Iuga, A Seicean Serum Interleukin (IL)-23 and IL-17 Profile in Inflammatory Bowel Disease (IBD) Patients Could Differentiate between Severe and Non-Severe Disease Journal of personalized medicine, 2021-11-02;11(11):. 2021-11-02 [PMID: 34834482] (Human)
• VR Ribeiro, M Romao-Veig, PR Nunes, ML Matias, JC Peracoli, MTS Peracoli Vitamin D modulates the transcription factors of T cell subsets to anti-inflammatory and regulatory profiles in preeclampsia International immunopharmacology, 2021-11-20;0(0):108366. 2021-11-20 [PMID: 34810124] (Human)
• C Liu, H Huang, Y Li, H Zhao The relationship of long non-coding RNA maternally expressed gene 3 with microRNA-21 and their correlation with acute ischemic stroke risk, disease severity and recurrence risk Clinical neurology and neurosurgery, 2021-09-11;210(0):106940. 2021-09-11 [PMID: 34607195] (Human)
• IS Ribeiro, ÍS Pereira, MPL Galantini, DP Santos, MF Teles, IPR Muniz, GS Santos, RAA Silva Regular physical activity reduces the effects of inflammaging in diabetic and hypertensive men Experimental gerontology, 2021-09-20;155(0):111558. 2021-09-20 [PMID: 34547405] (Human)
• L Bertran, M Portillo-C, S Martínez, C Aguilar, M Lopez-Dupl, D Riesco, J Binetti, M Vives, F Sabench, D Del Castil, C Richart, T Auguet Expression of Jejunal Taste Receptors in Women with Morbid Obesity Nutrients, 2021-07-16;13(7):. 2021-07-16 [PMID: 34371946] (Human)
• E Margiotta, L Caldiroli, ML Callegari, F Miragoli, F Zanoni, S Armelloni, V Rizzo, P Messa, S Vettoretti Association of Sarcopenia and Gut Microbiota Composition in Older Patients with Advanced Chronic Kidney Disease, Investigation of the Interactions with Uremic Toxins, Inflammation and Oxidative Stress Toxins, 2021-07-08;13(7):. 2021-07-08 [PMID: 34357944] (Human)
• B Tu, B Yu, W Wang, J Li, F Yuan, J Zhu, C Fan Inhibition of IL-17 prevents the progression of traumatic heterotopic ossification Journal of Cellular and Molecular Medicine, 2021-06-29;0(0):. 2021-06-29 [PMID: 34189826] (Human)
• DPS Lopes, IS Ribeiro, DC Santos, FMS Lima, AA Santos, DSP Souza, DN Lopes, AO Prado, ÍS Pereira, DP Santos, GS Santos, RAA Silva Regular physical activity reduces the proinflammatory response in older women with diabetes and hypertension in the postmenopausal phase Experimental gerontology, 2021-06-11;152(0):111449. 2021-06-11 [PMID: 34126225] (Human)
• C Zhang, C Xu, L Gao, X Li, C Zhao Porphyromonas gingivalis lipopolysaccharide promotes T-hel per17 cell differentiation by upregulating Delta-like ligand 4 expression on CD14+ monocytes PeerJ, 2021-04-23;9(0):e11094. 2021-04-23 [PMID: 33981487] (Human)
• J Zhou, N Zhang, W Zhang, C Lu, F Xu The YAP/HIF-1&alpha/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation Cell & bioscience, 2021-05-12;11(1):84. 2021-05-12 [PMID: 33980319] (Human)
• BK Jeong, JH Kim, MH Jung, KM Kang, YH Lee Cytokine Profiles of Non-Small Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy with Regards to Radiation Pneumonitis Severity Journal of Clinical Medicine, 2021-02-11;10(4):. 2021-02-11 [PMID: 33670117] (Human)
• M Ga?ecka, K Bli?niewsk, A Orzechowsk, J Szemraj, M Maes, M Berk, KP Su, P Ga?ecki Inflammatory versus Anti-inflammatory Profiles in Major Depressive Disorders-The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3 Journal of personalized medicine, 2021-01-23;11(2):. 2021-01-23 [PMID: 33498653] (Human)
• J Sun, H Jia, X Bao, Y Wu, T Zhu, R Li, H Zhao Tumor exosome promotes Th17 cell differentiation by transmitting the lncRNA CRNDE-h in colorectal cancer Cell Death & Disease, 2021-01-25;12(1):123. 2021-01-25 [PMID: 33495437] (Human)
• A Helmke, AM Hüsing, S Gaedcke, N Brauns, MS Balzer, M Reinhardt, M Hiss, N Shushakova, D de Luca, I Prinz, H Haller, S von Vietin Peritoneal dialysate-range hypertonic glucose promotes T cell IL-17 production that induces mesothelial inflammation Eur. J. Immunol., 2020-09-30;0(0):. 2020-09-30 [PMID: 32926407] (Human)
• M ?ychowska, A Batycka-Ba, W Baran Increased Serum Level and High Tissue Immunoexpression of Interleukin 17 in Cutaneous Lichen Planus: A Novel Therapeutic Target for Recalcitrant Cases? Dis. Markers, 2020-07-24;2020(0):6521274. 2020-07-24 [PMID: 32774513] (Human)
• A Sa?kowska, K Kara?, I Karwaciak, A Walczak-Dr, M Krawczyk, M Sobalska-K, J Dastych, M Ratajewski Identification of Novel Molecular Markers of Human Th17 Cells Cells, 2020-07-03;9(7):. 2020-07-03 [PMID: 32635226] (Human)
• MO Kutuk, E Tufan, C Gokcen, F Kilicaslan, M Karadag, T Mutluer, C Yektas, N Coban, H Kandemir, A Buber, S Coskun, U Acikbas, G Guler, Z Topal, F Celik, E Altintas, A Giray, Y Aka, O Kutuk Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey Cytokine, 2020-06-18;133(0):155152. 2020-06-18 [PMID: 32563959] (Human)
• T Auguet, L Bertran, J Binetti, C Aguilar, S Martínez, F Sabench, JM Lopez-Dupl, JA Porras, D Riesco, D Del Castil, C Richart Relationship between IL-8 Circulating Levels and TLR2 Hepatic Expression in Women with Morbid Obesity and Nonalcoholic Steatohepatitis Int J Mol Sci, 2020-06-11;21(11):. 2020-06-11 [PMID: 32545403] (Human)
• E Dozio, E Passeri, E Vianello, S Palmieri, C Eller-Vain, M Corsi Roma, S Corbetta Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism Mediators Inflamm., 2020-01-17;2020(0):3417329. 2020-01-17 [PMID: 32256191] (Human)
• C Liu, X Guo, S Bai, G Zeng, H Wang lncRNA CASC2 downregulation participates in rheumatoid arthritis, and CASC2 overexpression promotes the apoptosis of fibroblast?like synoviocytes by downregulating IL?17 Mol Med Rep, 2020-03-10;0(0):. 2020-03-10 [PMID: 32186765] (Human)
• A Gabsi, X Heim, A Dlala, A Gati, H Sakhri, A Abidi, S Amri, B Neili, AS Leroyer, A Bertaud, M Smiti Khan, F Said, MH Houman, B Granel, M Blot-Chaba, N Bardin, R Marrakchi TH17 cells�expressing CD146 are significantly increased in patients with Systemic sclerosis Sci Rep, 2019-11-27;9(1):17721. 2019-11-27 [PMID: 31776424] (Human)
• IS Ribeiro, ÍS Pereira, DP Santos, DS Lopes, AO Prado, SPM Calado, CV Gonçalves, MPL Galantini, IPR Muniz, GS Santos, RAA Silva Association between body composition and inflammation: A central role of IL-17 and IL-10 in diabetic and hypertensive elderly women Exp. Gerontol., 2019-09-10;127(0):110734. 2019-09-10 [PMID: 31518664] (Human)
• H Yu, S Cui, Y Mei, Q Li, L Wu, S Duan, G Cai, H Zhu, B Fu, L Zhang, Z Feng, X Chen Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses J Immunol Res, 2019-06-17;2019(0):2121849. 2019-06-17 [PMID: 31317046] (Human)
• S Vettoretti, L Caldiroli, S Armelloni, C Ferrari, M Cesari, P Messa Sarcopenia is Associated with Malnutrition but Not with Systemic Inflammation in Older Persons with Advanced CKD Nutrients, 2019-06-19;11(6):. 2019-06-19 [PMID: 31248132] (Human)
• JK Sun, WH Zhang, WX Chen, X Wang, XW Mu Effects of early enteral nutrition on Th17/Treg cells and IL-23/IL-17 in septic patients World J. Gastroenterol., 2019-06-14;25(22):2799-2808. 2019-06-14 [PMID: 31236002] (Human)
• DP Muñoz, SM Yannone, A Daemen, Y Sun, F Vakar-Lope, M Kawahara, AM Freund, F Rodier, JD Wu, PY Desprez, DH Raulet, PS Nelson, LJ van 't Vee, J Campisi, JP Coppé Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging JCI Insight, 2019-06-11;5(0):. 2019-06-11 [PMID: 31184599] (Human)
• T Huang, J Wang, Y Zhou, Y Zhao, D Hang, Y Cao LncRNA�CASC2 is upregulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis Biosci. Rep., 2019-05-14;0(0):. 2019-05-14 [PMID: 31015370] (Human)
• S Clayton, E Cauble, A Kumar, N Patil, D Ledford, N Kolliputi, MF Lopes-Vire, D Castell, J Richter Plasma levels of TNF-?, IL-6, IFN-?, IL-12, IL-17, IL-22, and IL-23 in achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD) BMC Gastroenterol, 2019-02-11;19(1):28. 2019-02-11 [PMID: 30744559] (Human)
• K Kara?, A Sa?kowska, M Sobalska-K, A Walczak-Dr, D Strapagiel, J Dastych, RA Bachorz, M Ratajewski Digoxin, an Overlooked Agonist of ROR?/ROR?T Front Pharmacol, 2019-01-07;9(0):1460. 2019-01-07 [PMID: 30666196] (Human)
• G Anzalone, GD Albano, AM Montalbano, L Riccobono, A Bonanno, R Gagliardo, F Bucchieri, R Marchese, M Moscato, M Profita IL-17A-associated IKK-? signaling induced TSLP production in epithelial cells of COPD patients Exp. Mol. Med., 2018-10-05;50(10):131. 2018-10-05 [PMID: 30291224] (Human)
• Wang J, Wu G, Manick B, Hernandez V, Renelt M, Erickson C, Guan J, Singh R, Rollins S, Solorz A, Bi M, Li J, Grabowski D, Dirkx J, Tracy C, Stuart T, Ellinghuysen C, Desmond D, Foster C, Kalabokis V VSIG-3 as a ligand of VISTA inhibits human T-cell function. Immunology, 2018-10-10;156(1):74-85. 2018-10-10 [PMID: 30220083] (Human)
• L Qian Decreased interleukin-11 levels in the semen of infertile males Cytokine, 2018-03-22;108(0):57-59. 2018-03-22 [PMID: 29573586] (Human)
• Y Liu, Q Zhao, Y Yin, MA McNutt, T Zhang, Y Cao Serum levels of IL-17 are elevated in patients with acute gouty arthritis Biochem. Biophys. Res. Commun., 2018-03-11;497(3):897-902. 2018-03-11 [PMID: 29476737] (Human)
• RJW Arts, SJCFM Moorlag, B Novakovic, Y Li, SY Wang, M Oosting, V Kumar, RJ Xavier, C Wijmenga, LAB Joosten, CBEM Reusken, CS Benn, P Aaby, MP Koopmans, HG Stunnenber, R van Crevel, MG Netea BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity Cell Host Microbe, 2018-01-10;23(1):89-100.e5. 2018-01-10 [PMID: 29324233] (Human)
• Ewa Kuca-Warna, Weronika Kurowska, Monika Prochorec, Anna Radzikows, Tomasz Burakowsk, Urszula Skalska, Magdalena Massalska, Magdalena Pleba?czy, Barbara Ma?dyk-No, Iwona S?owi?ska, Robert Gasik, W?odzimierz Ma?li?ski Rheumatoid arthritis bone marrow environment supports Th17 response. Arthritis Research & Therapy, 2017-12-08;0(0):1478-6362. 2017-12-08 [PMID: 29216915] (Human)
• U Bughani, A Saha, A Kuriakose, R Nair, RB Sadashivar, R Venkataram, S Patel, AT Deshchougu, SK S, E Montero, HV Pai, DV Palanivelu, R Melarkode, P Nair T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab PLoS ONE, 2017-07-03;12(7):e0180088. 2017-07-03 [PMID: 28672038] (Human)
• Z Meng, Y Zhang, Z Wei, P Liu, J Kang, Y Zhang, D Ma, C Ke, Y Chen, J Luo, Z Gong High serum resistin associates with intrahepatic inflammation and necrosis: an index of disease severity for patients with chronic HBV infection BMC Gastroenterol, 2017-01-07;17(1):6. 2017-01-07 [PMID: 28061755] (Human)
• YW Ji, SK Mittal, HS Hwang, EJ Chang, JH Lee, Y Seo, A Yeo, H Noh, HS Lee, SK Chauhan, HK Lee Lacrimal gland-derived IL-22 regulates IL-17-mediated ocular mucosal inflammation Mucosal Immunol, 2017-01-04;0(0):. 2017-01-04 [PMID: 28051088] (Human, Mouse)
• ?ukasz Matusiak Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents J. Am. Acad. Dermatol, 2016-12-29;0(0):. 2016-12-29 [PMID: 28041632] (Human)
• Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol J Exp Clin Cancer Res, 2016-07-22;35(1):118. 2016-07-22 [PMID: 27448598] (Human)
• Marcin Ratajewski Expression of human gene coding ROR?T receptor depends on the Sp2 transcription factor J Leukoc Biol, 2016-06-02;0(0):. 2016-06-02 [PMID: 27256574] (Human)
• Li W, Liu H CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma. Scand J Immunol, 2016-01-01;83(1):33-7. 2016-01-01 [PMID: 26331965] (Human)
• Zhao R, Chen N, Zhou X, Miao P, Hu C, Qian L, Yu Q, Zhang J, Nie H, Chen X, Li P, Xu R, Xiao L, Zhang X, Liu J, Zhang D Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model. J Transl Med, 2014-12-10;12(1):330. 2014-12-10 [PMID: 25491303] (Human)
• Chou C, Lin F, Tsai H, Chang S The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia. BMC Pulm Med, 2014-11-19;14(0):182. 2014-11-19 [PMID: 25409888] (Human)
• Schiavoni I, Fedele G, Quattrini A, Bianco M, Schnoeller C, Openshaw P, Locht C, Ausiello C Live attenuated B. pertussis BPZE1 rescues the immune functions of Respiratory Syncytial virus infected human dendritic cells by promoting Th1/Th17 responses. PLoS ONE, 2014-06-26;9(6):e100166. 2014-06-26 [PMID: 24967823] (Human)
• Wu W, Jin M, Wang Y, Liu B, Shen D, Chen P, Hannes S, Li Z, Hirani S, Jawad S, Sen H, Chan C, Nussenblatt R, Wei L Overexpression of IL-17RC associated with ocular sarcoidosis. J Transl Med, 2014-05-31;12(0):152. 2014-05-31 [PMID: 24885153] (Human)
• Ballantine L, Ong J, Midgley A, Watson L, Flanagan B, Beresford M The pro-inflammatory potential of T cells in juvenile-onset systemic lupus erythematosus. Pediatr Rheumatol Online J, 2014-01-16;12(0):4. 2014-01-16 [PMID: 24433387] (Human)
• Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol, 2014-02-01;44(2):370-85. 2014-02-01 [PMID: 24338958] (Human)
• Kleinnijenhuis J, Quintin J, Preijers F, Benn C, Joosten L, Jacobs C, van Loenhout J, Xavier R, Aaby P, van der Meer J, van Crevel R, Netea M Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity. J Innate Immun, 2013-10-30;6(2):152-8. 2013-10-30 [PMID: 24192057] (Human)
• Vincenzi F, Corciulo C, Targa M, Merighi S, Gessi S, Casetta I, Gentile M, Granieri E, Borea P, Varani K Multiple sclerosis lymphocytes upregulate A2A adenosine receptors that are antiinflammatory when stimulated. Eur J Immunol, 2013-06-03;43(8):2206-16. 2013-06-03 [PMID: 23661562] (Human)
• Zheng M, Zhang Z, Bemis K, Belch A, Pilarski L, Shively J, Kirshner J The systemic cytokine environment is permanently altered in multiple myeloma. PLoS ONE, 2013-03-27;8(3):e58504. 2013-03-27 [PMID: 23544044] (Human)
• Al-Ayadhi LY, Mostafa GA Elevated serum levels of interleukin-17A in children with autism. J Neuroinflammation, 2012-07-02;9(1):158. 2012-07-02 [PMID: 22748016] (Human)
• Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. Clin. Cancer Res., 2011-11-02;17(24):7529-38. 2011-11-02 [PMID: 22048239] (Human)
• Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA Identification of human NK17/NK1 cells. PLoS ONE, 2011-10-21;6(10):e26780. 2011-10-21 [PMID: 22039549] (Human)
• Lee N, Wong CK, Chan PK, Chan MC, Wong RY, Lun SW, Ngai KL, Lui GC, Wong BC, Lee SK, Choi KW, Hui DS Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults. PLoS ONE, 2011-10-13;6(10):e26050. 2011-10-13 [PMID: 22022504] (Human)
• Liu B, Wei L, Meyerle C, Tuo J, Sen HN, Li Z, Chakrabarty S, Agron E, Chan CC, Klein ML, Chew E, Ferris F, Nussenblatt RB Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration. J Transl Med, 2011-07-15;9(0):111. 2011-07-15 [PMID: 21762495] (Human)
• Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients. Arch. Dermatol. Res., 2011-06-17;303(6):451-5. 2011-06-17 [PMID: 21681565] (Human)
• Fridman JS, Scherle PA, Collins R, Burn T, Neilan CL, Hertel D, Contel N, Haley P, Thomas B, Shi J, Collier P, Rodgers JD, Shepard S, Metcalf B, Hollis G, Newton RC, Yeleswaram S, Friedman SM, Vaddi K Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation. J. Invest. Dermatol., 2011-06-16;131(9):1838-44. 2011-06-16 [PMID: 21677670] (Human)
• Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H, Hamad A, Chakravarti S Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS ONE, 2011-01-27;6(1):e16437. 2011-01-27 [PMID: 21298010] (Human)
• Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J. Allergy Clin. Immunol., 2010-11-01;126(5):962. 2010-11-01 [PMID: 20810157] (Human)
• Zhang G, Wang J, Kelly J B7-h3 augments the inflammatory response and is associated with human sepsis. J. Immunol., 2010-08-09;185(6):3677-84. 2010-08-09 [PMID: 20696859] (Human)
• Doe C, Bafadhel M, Siddiqui S, Desai D, Mistry V, Rugman P, McCormick M, Woods J, May R, Sleeman MA, Anderson IK, Brightling CE Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest, 2010-06-10;138(5):1140-7. 2010-06-10 [PMID: 20538817] (Human)
• Bakker GC, van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, Kooistra T, van Ommen B, Hendriks HF An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. Am. J. Clin. Nutr., 2010-02-24;91(4):1044-59. 2010-02-24 [PMID: 20181810] (Human)
• Xu G, Zhang L, Wang DY, Xu R, Liu Z, Han DM, Wang XD, Zuo KJ, Li HB Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells. Allergy, 2009-11-25;65(5):581-9. 2009-11-25 [PMID: 19968632] (Human)
• Lee WW, Kang SW, Choi J Regulating human Th17 cells via differential expression of IL-1 receptor. Blood, 2009-11-12;115(3):530-40. 2009-11-12 [PMID: 19965648] (Human)
• Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria. Transplantation, 2009-11-15;88(9):1109-16. 2009-11-15 [PMID: 19898207] (Human)
• Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur. J. Immunol., 2009-12-01;39(12):3570-81. 2009-12-01 [PMID: 19830738] (Human)
• Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis. Arthritis Rheum., 2009-06-01;60(6):1615-23. 2009-06-01 [PMID: 19479878] (Human)
• Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J. Exp. Med., 2009-03-09;206(3):535-48. 2009-03-09 [PMID: 19273625] (Human)
• Shahrara S, Pickens SR, Dorfleutner A, Pope RM IL-17 induces monocyte migration in rheumatoid arthritis. J. Immunol., 2009-03-15;182(6):3884-91. 2009-03-15 [PMID: 19265168] (Human)
• Ciprandi G, De Amici M, Murdaca G, Fenoglio D, Ricciardolo F, Marseglia G, Tosca M Serum interleukin-17 levels are related to clinical severity in allergic rhinitis. Allergy, 2009-02-17;64(9):1375-8. 2009-02-17 [PMID: 19226302] (Human)
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FAQs for IL-17/IL-17A (D1700). (Showing 1 - 3 of 3 FAQs).

1. I want to stain some T cell subsets (Th17 and Th1), do you have antibodies for that? I need for flow cytometer in sheep or goat.
   • Unfortunately, we have neither a CD4 antibody nor an IL-17 antibody that has been validated in sheep or goat, although if you would like to try one you would again be eligible for our Innovators Reward Program. Please contact us at innovators@novusbio.com with any questions regarding this program.
2. I'm looking to establish an ELISA for IL-17 and want your recommendation on which antibody pairs to buy. Least expensive ones, please. Also, I'd like the detection antibody to be fluorescently labeled.
   • Thank you for your patience while I reviewed our ELISA validated products for IL17. I was not sure what species you were going to be investigating, so I looked up our data for the human protein. If this is incorrect, just let me know and I can look up products for the species you will be working with. As for antibody pairs, we only had one set that have been tested together: Capture: NBP2-22531 Detection: NBP2-22532. The detection product is only available currently with a biotin conjugate. We can however offer custom conjugation for this product to any of our available conjugates. Please see the this link to see the available fluors. The typical fee for custom conjugation is usually about $80 additional. Once you know which fluor you would like, I can provide you with a quote. We do also offer several ELISA kits for this target (they typically employ HRP or Biotin detection systems, so I am not sure if they will work for your needs).
3. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: IL17A