HDAC7 [p Ser448] Antibody

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Western Blot: HDAC7 [p Ser448] Antibody [NBP2-03979] - Analysis of phosphorylated HDAC-7 in (A) recombinant fusion protein containing Ser448 and (B) fusion protein without the phosphorylated amino acid, using this ...read more

Product Details

Summary
Reactivity Hu, Rt, Bv, Ca, Eq, Pm, MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

HDAC7 [p Ser448] Antibody Summary

Immunogen
Within the range of amino acids 443-460 of human HDAC-7 protein were used as the immunogen ('b' represents a phosphorylated serine at position 448).
Epitope
CLSRAQbSPAA
Modification
p Ser448
Predicted Species
Mouse (90%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HDAC7
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1-0.5 ug/ml

Reactivity Notes

Reacts with Chimpanzee, Cow, Dog, Horse, Human, New World Monkey and Rat. Predicted to react with Mouse. The amino acid sequence used as immunogen is 100% homologous in Human, Monkey, Cow, Dog, Chimpanzee and Horse and 90% homologous in Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.1 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for HDAC7 [p Ser448] Antibody

  • DKFZP586J0917
  • EC 3.5.1.98
  • HD7
  • HD7A
  • HDAC7AFLJ99588
  • histone deacetylase 7
  • Histone deacetylase 7ADKFZp586J0917

Background

Histone deacetylase 7 is a thymus-specific, intracellular transcription factor belonging to the class IIa histone deacetylase family. Reports suggest that dephosphorylation and nuclear localization of HDAC-7 is promoted by Myosin phosphatase, thus regulating the repression of Nur77 and inhibition of apoptosis in CD4+CD8+ double-positive thymocytes. HDAC-7 plays a specific role in maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10. It promotes repression mediated by transcriptional corepressor NCOR2 and is an efficient corepressor of the androgen receptor (AR). It is also responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for HDAC7 Antibody (NBP2-03979). (Showing 1 - 1 of 1 FAQ).

  1. I'm interested in NBP2-03979. I would like to know whether it can be used for mouse brain tissue by WB. Have you ever tested it with mouse sample?
    • Our HDAC7 (pSer448) antibody with catalogue number NBP2-03979 has not yet been tested with mouse samples. However since the homology between the peptide immunogen and the mouse protein sequence is very high, at 90%, we do guarantee this antibody for use with mouse samples.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol HDAC7
Uniprot