Growth Hormone R Antibody (S02-6E6)

Western Blot: Growth Hormone R Antibody (S02-6E6) [NBP3-19651] - Western blot detection of Growth Hormone R in Rat Brain lysates using NBP3-19651 (1:500 diluted). Predicted band size: 72kDa. Observed band size: 120kDa.

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: S02-6E6
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.3 mg/ml

Growth Hormone R Antibody (S02-6E6) Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthetic peptide of human Growth Hormone R (Uniprot # P10912)
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: GHR
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1/1000-1/5000
• Theoretical MW: 120 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA
• Preservative: 0.01% Sodium Azide
• Concentration: 0.3 mg/ml
• Purity: Affinity purified

Alternate Names for Growth Hormone R Antibody (S02-6E6)

• GH receptor
• GHBP
• GHR
• growth hormone binding protein
• Growth Hormone R
• growth hormone receptor
• serum binding protein
• Somatotropin receptor

Background

Growth hormone receptor encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GHR