Human IGFBP-3 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Catalog# & Conjugate Size Price

Human IGFBP-3 Quantikine ELISA Kit Summary

Background
The Quantikine Human IGFBP-3 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human IGFBP-3 in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human IGFBP-3 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IGFBP-3 showed linear curves that were parallel to the standard curves obtained usi...ng the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human IGFBP-3.
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Specificity
Natural and recombinant human IGFBP-3
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
IGFBP3

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using
DGB300 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IGFBP-3 Quantikine ELISA Kit

  • acid stable subunit of the 140 K IGF complex
  • binding protein 29
  • binding protein 53
  • growth hormone-dependent binding protein
  • IBP-3
  • IBP3BP-53
  • IGF-binding protein 3
  • IGFBP3
  • IGFBP-3
  • insulin-like growth factor binding protein 3
  • insulin-like growth factor-binding protein 3

Background

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IGFBP-3 (DGB300)(32)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA Capture.


Filter By Application
ELISA Capture
(1)
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Filter By Species
Human
(32)
All Species
Showing Publications 1 - 10 of 32. Show All 32 Publications.
Publications using DGB300 Applications Species
A Malin Igra, M Vahter, R Raqib, M Kippler Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children Environ. Health Perspect., 2019;127(3):37003. 2019 [PMID: 30848671] (Human) Human
RH Bartels, E Chimwezi, V Watson, L Pei, I Potani, B Allubha, K Chidzalo, D Wang, Q Dube, M Mallewa, A Allen, RHJ Bandsma, WP Voskuijl, SJ Allen Hypoallergenic and anti-inflammatory feeds in children with complicated severe acute malnutrition: an open randomised controlled 3-arm intervention trial in Malawi Sci Rep, 2019;9(1):2304. 2019 [PMID: 30783173] (Human) Human
M Krause, D Crognale, K Cogan, S Contarelli, B Egan, P Newsholme, G De Vito The effects of a combined bodyweight-based and elastic bands resistance training, with or without protein supplementation, on muscle mass, signaling and heat shock response in healthy older people Exp. Gerontol., 2018;115(0):104-113. 2018 [PMID: 30529477] (Human) Human
MD DeBoer, AM Lee, K Herbert, J Long, M Thayu, LM Griffin, RN Baldassano, LA Denson, BS Zemel, MR Denburg, R Herskovitz, MB Leonard Increases in IGF-1 after Anti-TNF-? Therapy are Associated with Bone and Muscle Accrual in Pediatric Crohn's Disease J. Clin. Endocrinol. Metab., 2018;0(0):. 2018 [PMID: 29329430] (Human) Human
G Annibalini, F Lucertini, D Agostini, L Vallorani, A Gioacchini, E Barbieri, M Guescini, L Casadei, A Passalia, M Del Sal, G Piccoli, M Andreani, A Federici, V Stocchi Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients Oxid Med Cell Longev, 2017;2017(0):3937842. 2017 [PMID: 28713486] (Human) Human
JR Gee, DR Saltzstein, K Kim, JM Kolesar, W Huang, TC Havighurst, BW Wollmer, J Stublaski, T Downs, H Mukhtar, M House, HL Parnes, HH Bailey A phase II randomized, double-blind, presurgical trial of Polyphenon E in bladder cancer patients to evaluate pharmacodynamics and bladder tissue biomarkers Cancer Prev Res (Phila), 2017;0(0):. 2017 [PMID: 28325826] (Human) Human
A Olszanecka, A Dragan, K Kawecka-Ja, D Fedak, D Czarnecka Relationships of insulin-like growth factor-1, its binding proteins, and cardiometabolic risk in hypertensive perimenopausal women Metab. Clin. Exp., 2017;69(0):96-106. 2017 [PMID: 28285656] (Human) Human
S Sakimoto, V Marchetti, E Aguilar, K Lee, Y Usui, S Murinello, F Bucher, JK Trombley, R Fallon, R Wagey, C Peters, EL Scheppke, PD Westenskow, M Friedlande CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect JCI Insight, 2017;2(2):e89906. 2017 [PMID: 28138561] (Human) Human
Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population Sci Rep, 2016;6(0):39014. 2016 [PMID: 27976731] (Human) Human
Ge Sheng Cheng Bone marrow-derived mesenchymal stem cells modified with IGFBP-3 inhibit the proliferation of pulmonary artery smooth muscle cells Int. J. Mol. Med, 2017;39(1):223-230. 2017 [PMID: 27959432] (Human) Human
Show All 32 Publications.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for IGFBP-3 (DGB300). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DGB300
HRP DGB300
HRP DGB300

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Bioinformatics

Gene Symbol IGFBP3