Human IGFBP-3 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Catalog# & Conjugate Size Price

Human IGFBP-3 Quantikine ELISA Kit Summary

Background
The Quantikine Human IGFBP-3 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human IGFBP-3 in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human IGFBP-3 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IGFBP-3 showed linear curves that were parallel to the standard curves obtained usi...ng the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human IGFBP-3.
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Specificity
Natural and recombinant human IGFBP-3
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
IGFBP3

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using
DGB300 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IGFBP-3 Quantikine ELISA Kit

  • acid stable subunit of the 140 K IGF complex
  • binding protein 29
  • binding protein 53
  • growth hormone-dependent binding protein
  • IBP-3
  • IBP3BP-53
  • IGF-binding protein 3
  • IGFBP3
  • IGFBP-3
  • insulin-like growth factor binding protein 3
  • insulin-like growth factor-binding protein 3

Background

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IGFBP-3 (DGB300)(40)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA Capture.


Filter By Application
ELISA Capture
(1)
All Applications
Filter By Species
Human
(40)
All Species
Showing Publications 1 - 10 of 40. Show All 40 Publications.
Publications using DGB300 Applications Species
WL Stuard, MK Guner, DM Robertson IGFBP-3 Regulates Mitochondrial Hyperfusion and Metabolic Activity in Ocular Surface Epithelia during Hyperosmolar Stress International Journal of Molecular Sciences, 2022;23(7):. 2022 [PMID: 35409425] (Human) Human
JA Goldsmith, RE Lai, RS Garten, Q Chen, EJ Lesnefsky, RA Perera, AS Gorgey Visceral Adiposity, Inflammation, and Testosterone Predict Skeletal Muscle Mitochondrial Mass and Activity in Chronic Spinal Cord Injury Frontiers in Physiology, 2022;13(0):809845. 2022 [PMID: 35222077] (Human) Human
ED Bogdan, WL Stuard, R Titone, DM Robertson IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium Investigative Ophthalmology & Visual Science, 2021;62(7):11. 2021 [PMID: 34100890] (Human) Human
J Yang, C Yang, H Shen, W Wu, Z Tian, Q Xu, C Cao, S Ye, L Ban, X Tong, J Mei Discovery and validation of PZP as a novel serum biomarker for screening lung adenocarcinoma in type 2 diabetes mellitus patients Cancer Cell International, 2021;21(1):162. 2021 [PMID: 33691685] (Human) Human
KR Monson, M Goldberg, HC Wu, RM Santella, WK Chung, MB Terry Circulating growth factor concentrations and breast cancer risk: a nested case-control study of IGF-1, IGFBP-3, and breast cancer in a family-based cohort Breast Cancer Res, 2020;22(1):109. 2020 [PMID: 33092613] (Human) Human
F Buckinx, LP Carvalho, V Marcangeli, M Dulac, G Hajj Boutr, G Gouspillou, P Gaudreau, P Noirez, M Aubertin-L High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults Exp. Gerontol., 2020;0(0):111036. 2020 [PMID: 32721549] (Human) Human
Z Zeng, X Huo, Q Wang, C Wang, MN Hylkema, X Xu PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height Environ Int, 2020;138(0):105660. 2020 [PMID: 32199227] (Human) Human
J Sakata, A Hirosue, R Yoshida, Y Matsuoka, K Kawahara, H Arita, H Nakashima, T Yamamoto, M Nagata, S Kawaguchi, S Gohara, Y Nagao, K Yamana, R Toya, R Murakami, Y Kuwahara, M Fukumoto, H Nakayama Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Cancers (Basel), 2020;12(2):. 2020 [PMID: 32093285] (Human) Human
A Malin Igra, M Vahter, R Raqib, M Kippler Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children Environ. Health Perspect., 2019;127(3):37003. 2019 [PMID: 30848671] (Human) Human
RH Bartels, E Chimwezi, V Watson, L Pei, I Potani, B Allubha, K Chidzalo, D Wang, Q Dube, M Mallewa, A Allen, RHJ Bandsma, WP Voskuijl, SJ Allen Hypoallergenic and anti-inflammatory feeds in children with complicated severe acute malnutrition: an open randomised controlled 3-arm intervention trial in Malawi Sci Rep, 2019;9(1):2304. 2019 [PMID: 30783173] (Human) Human
Show All 40 Publications.

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Bioinformatics

Gene Symbol IGFBP3