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CTS008) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections." class="big_lightbox" target="_blank">
1210-GR) inhibits Recombinant Human Growth Hormone (Catalog # 1067-GH) induced proliferation in the Nb2-11 rat lymphoma cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Human Growth Hormone (0.2 ng/mL) activity elicited by Recombinant Human Growth Hormone R/GHR Fc Chimera (10 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human Growth Hormone R/GHR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1210). The ND50 is typically 0.125-0.5 µg/mL." class="big_lightbox" target="_blank">
1211-GR) inhibits Recombinant Human Growth Hormone (Catalog # 1067-GH) induced proliferation in the Nb2-11 rat lymphoma cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Human Growth Hormone (0.2 ng/mL) activity elicited by Recombinant Rat Growth Hormone R/GHR Fc Chimera (10 ng/mL) is neutralized (green line) by increasing concen-trations of Goat Anti-Rat Growth Hormone R/GHR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1211). The ND50 is typically 0.075-0.3 µg/mL." class="big_lightbox" target="_blank">
Growth hormone receptor encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.
![Neutralization Growth Hormone R Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Growth_Hormone_R_AF1210_Block_Neutralize_271.jpg)
