GRID2 Antibody - BSA Free

Immunohistochemistry-Paraffin: GRID2 Antibody [NBP2-31723] - Staining of human testis shows high expression.

Immunohistochemistry-Paraffin: GRID2 Antibody [NBP2-31723] - Staining of human cerebellum shows distinct positivity in neuropil of the molecular layer.

Immunohistochemistry-Paraffin: GRID2 Antibody [NBP2-31723] - Staining of human endometrium shows low expression as expected.

Immunohistochemistry-Paraffin: GRID2 Antibody [NBP2-31723] - Staining in human testis and endometrium tissues using anti-GRID2 antibody. Corresponding GRID2 RNA-seq data are presented for the same tissues.

• Reactivity: Hu, Mu, Rt
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

GRID2 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against a recombinant protein corresponding to amino acids: AVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADR
• Predicted Species: Mouse (98%), Rat (98%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GRID2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  GRID2 Protein (NBP2-31723PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for GRID2 Antibody - BSA Free

• B230104L07Rik
• cpr
• creeper
• gluR delta-2 subunit
• GLURD2
• GluRdelta2
• glutamate receptor delta-2 subunit
• glutamate receptor, ionotropic, delta 2
• GRID2
• ho
• hotfoot
• Lc
• lurcher
• minisatellite 10ac detected by probe MMS10
• MMS10-AC
• Ms10ac
• nmf408
• SCAR18
• tpr

Background

Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamategated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits, designated GluR-1 to -7, as well as GluR-delta2. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: episilon1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four episilon subunits display limited distribution. In mice, mutations in the gene encoding GluR-delta2 (GRID2) cause the Lurcher phenotype. The gene encoding human GluR-delta2 maps to chromosome 4q22.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GRID2
• Uniprot:
  • O43424(Human)