GRID2 Products

Description

Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamategated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits, designated GluR-1 to -7, as well as GluR-delta2. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: episilon1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four episilon subunits display limited distribution. In mice, mutations in the gene encoding GluR-delta2 (GRID2) cause the Lurcher phenotype. The gene encoding human GluR-delta2 maps to chromosome 4q22.

Bioinformatics

Entrez	14804 Mouse 2895 Human 79220 Rat
Uniprot	NP_001501 Human O43424 Human
Product By Gene ID	2895
Alternate Names	B230104L07Rik cpr creeper gluR delta-2 subunit GluRdelta2 glutamate receptor delta-2 subunit glutamate receptor, ionotropic, delta 2 ho hotfoot Lc Lc lurcher minisatellite 10ac detected by probe MMS10 MMS10-AC Ms10ac nmf408 tpr

Research Areas for GRID2

Find related products by research area and learn more about each of the different research areas below.

Neuronal Cell Markers
Neurotransmission