Cerebellin-1/Precerebellin Antibody - BSA Free

Western Blot: Cerebellin-1/Precerebellin Antibody [NBP1-77238] - Analysis of precerebellin in 293 cell lysate with precerebellin antibody at (A) 2 and (B) 4 ug/ml.

Immunocytochemistry/ Immunofluorescence: Cerebellin-1/Precerebellin Antibody - BSA Free [NBP1-77238] - Immunocytochemistry of precerebellin in 3T3 cells with precerebellin antibody at 10 ug/mL.

• Reactivity: Hu, Mu, Rt, Bv
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Cerebellin-1/Precerebellin Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit Cerebellin-1/Precerebellin Antibody - BSA Free (NBP1-77238) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. Anti-Cerebellin-1/Precerebellin Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 16 amino acid synthetic peptide from near the carboxy- terminus human precerebellin. The immunogen is located within the last 50 amino acids of Precerebellin. Amino Acid Squence: QMEKGDRAYLKLERGN
• Predicted Species: Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CBLN1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 10 ug/mL
  • Western Blot 2-4 ug/ml
• Control Peptide:

  Cerebellin-1/Precerebellin Peptide (NBP1-77238PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for Cerebellin-1/Precerebellin Antibody - BSA Free

• CBLN1
• cerebellin 1 precursor
• Cerebellin1
• Cerebellin-1
• CLN1
• Precerebellin

Background

Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus. Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Cerebellin-1/Precerebellin Antibody (NBP1-77238)(1)

Publication using NBP1-77238

• Suriano CM, Bodznick D. Evidence for generative homology of cerebellum and cerebellum-like structures in an elasmobranch fish based on Pax6, Cbln1 and Grid2 expression J. Comp. Neurol. 2018-06-11 [PMID: 29888788]

Review for Cerebellin-1/Precerebellin Antibody (NBP1-77238) (1)

Average Rating: 4

(Based on 1 review)

We have 1 review tested in 1 species: Other.

reviewed by: Christos Suriano WB Other 02/09/2016

Summary

• Application: Western Blot
• Sample Tested: Skate brain
• Species: Other

Bioinformatics

• Gene Symbol: CBLN1
• Uniprot:
  • P23435()