GPER/GPR30 Antibody - BSA Free

Immunohistochemistry-Paraffin: GPER/GPR30 Antibody [NLS4268] - Analysis of anti-GPR30 antibody with human skeletal muscle at dilution 5 - 7.5 ug/ml.

Immunohistochemistry-Paraffin: GPER/GPR30 Antibody [NLS4268] - Analysis of anti-GPR30 antibody with human, spleen.

• Reactivity: Hu, Pm
• Applications: ELISA, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

GPER/GPR30 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 15 amino acid peptide from 2nd extracellular domain of human GPER/GPR30.
• Epitope: 2nd extracellular domain
• Localization: Endoplasmic reticulum - multi-pass membrane protein.
• Specificity: Human GPR30. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GPER1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5-7.5 ug/ml
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (93%), Mouse (87%), Rat (87%), Hamster (87%), Panda (87%), Equine (87%), Opossum (87%), Platypus (87%), Canine (80%), Bovine (80%), Turkey (80%), Zebra finch (80%), Chicken (80%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for GPER/GPR30 Antibody - BSA Free

• CEPR
• CEPRG-protein coupled receptor 30
• Chemoattractant receptor-like 2
• chemokine receptor-like 2
• CMKRL2
• CMKRL2MGC99678
• constitutively expressed peptide-like receptor
• DRY12
• DRY12IL8-related receptor DRY12
• FEG-1
• FEG-1mER
• Flow-induced endothelial G-protein coupled receptor 1
• G protein-coupled estrogen receptor 1
• G protein-coupled receptor 30
• GPCR-BR
• GPER
• GPR30
• GPR30GPCR-Br
• G-protein coupled estrogen receptor 1
• heptahelix receptor
• LERGU
• LERGU2
• leucine rich protein in GPR30 3'UTR
• LyGPR
• Lymphocyte-derived G-protein coupled receptor
• Membrane estrogen receptor

Background

GPR30 is a transmembrane intracellular estrogen receptor (Revankar et al. 2005). Progestin inhibits growth in breast cancer cells through GPR30. GPR30 has been reported in brain, breast carcinoma, blood, bone marrow, CNS, heart, liver, lung, lymph node, placenta, and spleen. ESTs have been isolated from B-cell/lung/testis, brain, ganglion, heart/melanocyte/uterus, kidney, tonsil, liver/spleen, placenta, and prostate libraries. Ligands: Estrogen (Revankar et al. 2005). Caution: Rat GPR30 is also known as GPR41 and HIA-R

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GPER/GPR30 Antibody (NLS4268)(1)

Publication using NLS4268

• Park II, Zhang Q, Liu V et al. 17{beta}-estradiol at low concentrations acts through distinct pathways in normal versus BPH-derived prostate stromal cells. Endocrinology :en.2008-1591. 2009-01-01 [PMID: 19608654]

Bioinformatics

• Gene Symbol: GPER1
• Entrez:
  • 2852(Human)
• Uniprot:
  • Q99527()