Dtk/TYRO3 Antibody [Unconjugated]


Tyro3/Dtk was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c, follicles of vibrissae associated with upper lip) using Goat Anti-Mouse Tyro3/Dtk Antigen Affinity-purified Polyclonal Antibody ...read more

Product Details

Reactivity MuSpecies Glossary
Applications WB, IHC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
View Available Formulations
Catalog# & Formulation Size Price

Dtk/TYRO3 Antibody [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant mouse Tyro3/Dtk
Accession # P55144
Detects mouse Tyro3/Dtk in direct ELISAs and Western blots. In direct ELISA and Western blots, approximately 20% cross-reactivity with recombinant human (rh) Tyro3/Dtk is observed, and less than 1% cross-reactivity with recombinant mouse (rm) Axl, rmMer and rhAxl is observed.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 0.1 ug/mL
  • Immunohistochemistry 5-15 ug/mL
Read Publications using
AF759 in the following applications:

  • 2 publications
  • IP
    1 publication
  • 1 publication
  • WB
    3 publications

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Dtk/TYRO3 Antibody [Unconjugated]

  • Brt
  • BYK
  • Dtk
  • EC 2.7.10
  • EC
  • FLJ16467
  • Rse
  • Sky
  • Tif
  • TYRO3 protein tyrosine kinase
  • Tyro3
  • Tyrosine-protein kinase byk
  • Tyrosine-protein kinase DTK
  • tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase RSE
  • Tyrosine-protein kinase SKY


Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.

  1. Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
  2. Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: WB, IHC, ICC
Species: Hu
Applications: WB, ELISA, IHC
Species: Mu
Applications: Flow, IHC, CyTOF-ready
Species: Hu, Rt, Mk, Pm
Applications: WB, IHC, IHC-P, IF
Species: Hu, Mu, Dr
Applications: WB, Simple Western, ChIP, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
Species: Hu, Mu, Bv, Ca, Fe
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu
Applications: WB, ELISA, ICC/IF
Species: Mu
Applications: WB, Simple Western, IHC
Species: Hu, Mu, Rt, Ye, Xp(-)
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready, Flow-IC
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow
Species: Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu
Applications: WB, Flow, IHC, IP, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ELISA(Sta)
Species: Hu
Applications: IHC, IHC-P
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu
Species: Mu
Applications: WB, IHC

Publications for Dtk/TYRO3 Antibody (AF759)(7)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Flow, IP, Neut, WB.

Filter By Application
All Applications
Filter By Species
All Species
Showing Publications 1 - 7 of 7.
Publications using AF759 Applications Species
Y Yanagihash, K Segawa, R Maeda, YI Nabeshima, S Nagata Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):. 2017 [PMID: 28768810] (WB,, Mouse) WB Mouse
A Voronova, SA Yuzwa, BS Wang, S Zahr, C Syal, J Wang, DR Kaplan, FD Miller Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain Neuron, 2017;94(3):500-516.e9. 2017 [PMID: 28472653] (Neut,, Mouse) Neut Mouse
Zagorska A, Traves P, Lew E, Dransfield I, Lemke G Diversification of TAM receptor tyrosine kinase function. Nat Immunol, 2014;15(10):920-8. 2014 [PMID: 25194421] (IP,, Mouse) IP Mouse
Paolino, Magdalen, Choidas, Axel, Wallner, Stephani, Pranjic, Blanka, Uribesalgo, Iris, Loeser, Stefanie, Jamieson, Amanda M, Langdon, Wallace, Ikeda, Fumiyo, Fededa, Juan Pab, Cronin, Shane J, Nitsch, Roberto, Schultz-Fademrecht, Carsten, Eickhoff, Jan, Menninger, Sascha, Unger, Anke, Torka, Robert, Gruber, Thomas, Hinterleitner, Reinhard, Baier, Gottfrie, Wolf, Dominik, Ullrich, Axel, Klebl, Bert M, Penninger, Josef M The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature, 2014;507(7493):508-12. 2014 [PMID: 24553136] (Flow,, Mouse) Flow Mouse
Zhong Z, Wang Y, Guo H, Sagare A, Fernandez JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J. Neurosci., 2010;30(46):15521-34. 2010 [PMID: 21084607] (WB,, Mouse) WB Mouse
Zhu D, Wang Y, Singh I Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood, 2010;115(23):4963-72. 2010 [PMID: 20348395] (WB,, Mouse) WB Mouse
Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. J. Thromb. Haemost., 2005;3(4):733-41. 2005 [PMID: 15733062] (Flow,, Mouse) Flow Mouse

Reviews for Dtk/TYRO3 Antibody (AF759) (0)

There are no reviews for Dtk/TYRO3 Antibody (AF759). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Dtk/TYRO3 Antibody (AF759) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Additional Array Products

Bioinformatics Tool for Dtk/TYRO3 Antibody (AF759)

Discover related pathways, diseases and genes to Dtk/TYRO3 Antibody (AF759). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Dtk/TYRO3 Antibody (AF759)

Discover more about diseases related to Dtk/TYRO3 Antibody (AF759).

Pathways for Dtk/TYRO3 Antibody (AF759)

View related products by pathway.

PTMs for Dtk/TYRO3 Antibody (AF759)

Learn more about PTMs related to Dtk/TYRO3 Antibody (AF759).

Blogs on Dtk/TYRO3

There are no specific blogs for Dtk/TYRO3, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Dtk/TYRO3 Antibody [Unconjugated] and receive a gift card or discount.


Gene Symbol Tyro3