GluR1 [p Ser845] Antibody (RM296)

Western Blot: GluR1 [p Ser845] Antibody (RM296) [NBP2-61472] - Western Blot of mouse brain tissue lysate, non-treated (-) or dephosphorylated (+) with Lambda Protein Phosphatase (lPP), using NBP2-61472 at a 1:200 dilution.

Immunohistochemistry-Paraffin: GluR1 [p Ser845] Antibody (RM296) [NBP2-61472] - Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using NBP2-61472 at a 1:200 dilution.

• Reactivity: Hu
• Applications: WB, IHC
• Clone: RM296
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

GluR1 [p Ser845] Antibody (RM296) Summary

• Description: Novus Biologicals Rabbit GluR1 [p Ser845] Antibody (RM296) (NBP2-61472) is a recombinant monoclonal antibody validated for use in IHC and WB. Anti-GluR1 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: A phospho-peptide corresponding to Human GluR1 [p Ser845]
• Modification: p Ser845
• Specificity: This antibody reacts to GluR1 only when phosphorylated at Ser845. There is no cross-reactivity to GluR1 that is not phosphorylated at Ser845.
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: GRIA1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin
  • Western Blot 1:1000-1:2000

Reactivity Notes

This antibody may also react to mouse or rat phospho-GluR1 [Ser845] as predicted by immunogen homology.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 50% Glycerol/PBS, 1% BSA
• Preservative: 0.09% Sodium Azide
• Purity: Protein A purified

Alternate Names for GluR1 [p Ser845] Antibody (RM296)

• AMPA 1
• AMPA-selective glutamate receptor 1
• GluA1
• GLUH1
• GluR1
• gluR-1
• GLUR1gluR-A
• GLURA
• GluR-A
• gluR-K1
• glutamate receptor 1
• Glutamate receptor ionotropic, AMPA 1
• glutamate receptor, ionotropic, AMPA 1
• GRIA1
• HBGR1
• MGC133252

Background

Glutamate Receptor 1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for Glutamate Receptor 1. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GluR1 Antibody (NBP2-61472)(1)

Publication using NBP2-61472

• Hafycz J, Strus E, Naidoo N Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer’s Disease mice bioRxiv 2023-05-25 [PMID: 37292838]

Bioinformatics

• Gene Symbol: GRIA1