GDF-11/GDF-8 Antibody (743835R) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 743835R
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

GDF-11/GDF-8 Antibody (743835R) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human GDF-11/GDF-8 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GDF-11/GDF-8 Antibody (743835R) [Alexa Fluor™ Plus 647]

• BMP11
• BMP-11
• bone morphogenetic protein 11
• GDF-11
• GDF-11/GDF-8
• growth/differentiation factor 11
• VHO

Background

Growth Differentiation Factor 11 (GDF-11), also known as BMP-11, is a member of the TGF-beta superfamily and is highly related to GDF-8. GDF-11 encodes a 407 amino acid (aa) prepropeptide processed into a 109 aa mature protein. Mature GDF-11 contains the canonical 7-cysteine motif common to other TGF-beta superfamily members; however, like the TGF-beta s, Activins and GDF-8, GDF-11 also contains one extra pair of cysteine residues. At the amino acid sequence level, mature human, mouse, rat and chicken GDF-11 are 99-100% identical. Mature GDF-11 and GDF-8 share 90% amino acid sequence identity. GDF-11 is expressed in diverse regions of the mouse embryo: tailbud, somitic precursors, limbs, mandibular and branchial arches, dorsal neural tube, odontoblasts, nasal epithelium, and particular regions of the brain (1). GDF-11 signals through the Activin type II receptors and induces phosphorylation of Smad2 to mediate axial patterning (2). Systemic GDF-11 levels decline with age and administration of higher levels of GDF-11 can reverse age-related cardiac hypertrophy (3). In addition, systemic administration of recombinant GDF-11 protein restores genomic integrity and health of muscle stem cells, neurovasculature and enhances neurogenesis (4, 5).

1. Nakashima, M. et al. (1999) Mech. Dev. 80:185.  
2. Oh, S.P. et al. (2002) Genes & Dev. 16:274.
3. Loffredo, F.S. et. al. (2013) Cell. 153.828.
4. Katsimpardi, L. et. al. (2014) Science. 344.630.
5. Sinha, M. et. al. (2014) Science. 344.649.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.