Recombinant Human GDF-11/BMP-11 Protein

Product Discontinued

Recombinant Human GDF-11/BMP-11 Protein Summary

• Description: A recombinant protein corresponding to 136 amino acids of Human GDF-11/BMP-11
• Preparation Method: >98% SDS-PAGE
• Details of Functionality: Biological Activity: The protein is biologically active as determined by its ability to induce alkaline phosphatase production by C2C12 cells. The ED50 is in the range of 0.4-4 ug/ml.
  Results: 0.4-4 ug/ml
• Protein/Peptide Type: Recombinant Protein
• Gene: GDF11
• Purity: >98%, by SDS-PAGE
• Endotoxin Note: <0.1 ng/ug

Applications/Dilutions

• Theoretical MW: 32.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: From 10 mM Sodium Citrate, pH 3.5.
• Concentration: Lyoph
• Purity: >98%, by SDS-PAGE
• Reconstitution Instructions: Reconstitute with water to a final concentration of 0.1 - 1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4C for 1 week or -20C for future use.

Notes

The purity of this protein is >95% pure by SDS-PAGE

Alternate Names for Recombinant Human GDF-11/BMP-11 Protein

• BMP11
• BMP-11
• BMP-11BMP11Bone morphogenetic protein 11
• GDF11
• GDF-11
• growth differentiation factor 11
• growth/differentiation factor 11

Background

BMPs (bone morphogenetic proteins) belong to the TGF-Beta superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Recombinant human BMP-11 is N-terminus His-tagged protein with a molecular weight of 32.6 kDa (for homodimeric) and 16.2 (for monomeric) consisting of 136 amino acid polypeptide chains.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GDF11