Galanin R2/GALR2 Antibody

Images

 
Western Blot: Galanin R2/GALR2 Antibody [NB100-57081] - (0.3ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Galanin R2/GALR2 Antibody Summary

Immunogen
Peptide with sequence C-RYPLHSRELRTPRN corresponding to internal region according to NP_003848.1.
Epitope
RYPLHSRELRTPRN
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
GALR2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.3 - 1 ug/ml
  • Peptide ELISA Detection limit 1:4000
Application Notes
WB: Approx. 40 kDa band observed in human heart lysates (calculated MW of 41.7 kDa band according to NP_003848.1).
Positive Control
Galanin R2/GALR2 Lysate (NBL1-10962)
Heart Lysate (NB820-59217)
Publications
Read Publication using NB100-57081.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Galanin R2/GALR2 Antibody

  • GAL2R
  • GAL2-R
  • Galanin R2
  • galanin receptor 2
  • galanin receptor type 2
  • GalaninR2
  • GALNR2
  • GALNR2MGC125984
  • GALR2
  • GALR-2
  • MGC125983

Background

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol GALR2
Entrez
Uniprot