Galanin R2/GALR2 Products

Description

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.

Bioinformatics

Entrez	8811 Human 14428 Mouse 29234 Rat
Uniprot	O43603 Human NP_003848.1 Human NM_003857 Human
Product By Gene ID	8811
Alternate Names	GALR-2 galanin receptor type 2 GAL2-R GALNR2MGC125984 MGC125983 galanin receptor 2

Diseases related to Galanin R2/GALR2

Discover more about diseases related to Galanin R2/GALR2.

Nervousness
Pain
Depressive Disorder
Neoplasms
Pituitary Diseases
Nerve Damage
Alzheimer's Disease
Anxiety Disorders
Epilepsy
Malignant Neoplasms
Neuralgia
Pertussis
Status Epilepticus
Obesity
Carcinoma
Peripheral Nerve Injuries
Mood Disorders
Malignant Squamous Cell Neoplasm
Major Depressive Disorder

Pathways for Galanin R2/GALR2

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Localization
Secretion
Cell Proliferation
Feeding Behavior
Cognition
Neurogenesis
Regeneration
Cell Death
Methylation
Reverse Transcription
Energy Homeostasis
Transport
Cell Cycle Arrest
Cell Cycle
Hormone Secretion
Lactation
Membrane Hyperpolarization
Neuroprotection
Cellular Localization
Innervation

Research Areas for Galanin R2/GALR2

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GPCR

PTMs for Galanin R2/GALR2

Learn more about PTMs related to Galanin R2/GALR2.

Phosphorylation
Methylation
Cleavage
Demethylation
Amidation

Bioinformatics Tool for Galanin R2/GALR2

Discover related pathways, diseases and genes to Galanin R2/GALR2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.