GABA-A R beta 2 Antibody

Images

 
Western Blot: GABA-A R beta 2 Antibody [NB300-198] - 7 ug of rat cerebellum (Cb) showing specific immunolabeling of the ~55k beta2-subunit of the GABA-AR.

Product Details

Summary
Reactivity Mu, Rt, Hu, Ca, PmSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

GABA-A R beta 2 Antibody Summary

Immunogen
Fusion protein from the cytoplasmic loop of the beta 2 subunit
Localization
Cell Membrane; multi pass membrane protein
Specificity
Specific for the ~55k beta 2-subunit of the GABAA receptor in Western blots.
Predicted Species
Human (100%), Canine (100%), Primate (100%). Backed by our 100% Guarantee.
Clonality
Polyclonal
Host
Rabbit
Gene
GABRB2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
Application Notes
Immunoprecipitation 15 ug ** ** 68% of all GABA-A receptors in dodecylsulfate extracts of rat forebrains (150 ul) The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NB300-198 in the following applications:

  • WB
    2 publications

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 16807363). It is anticipated that the antibody will react with canine, human and non-human primate based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for GABA-A R beta 2 Antibody

  • GABA A R beta 2
  • GABA(A) receptor subunit beta-2
  • GABAAR beta 2
  • GABAARb2
  • GABRB2
  • gamma-aminobutyric acid (GABA) A receptor, beta 2
  • gamma-aminobutyric acid A receptor beta 2
  • gamma-aminobutyric acid receptor subunit beta-2
  • MGC119386
  • MGC119388
  • MGC119389

Background

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GABA-A R beta 2 Antibody (NB300-198)(3)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.


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WB
(2)
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Mouse
(2)
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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for GABA-A R beta 2 Antibody (NB300-198). (Showing 1 - 1 of 1 FAQs).

  1. Could you please provide the immunogen sequence for Anti-GABA A Receptor beta 3 antibody and Anti-GABA A Receptor beta 2 antibody, catalog number NB300-199 and NB300-198 at your earliest convenience? If the exact sequence is not available, could you please tell me a broader range of amino acids or the region of the peptide from which it is derived? Also, please let me know if this information can be made public. Thank you for your help in this matter.
    • The immunogen for NB300-199 falls within 340-420 amino acids, while the immunogen for NB300-198 falls within the range of 327-451.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol GABRB2
Entrez
Uniprot

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