GABA-A R gamma 2 Antibody

Images

 
Western Blot: GABA-A R gamma 2 Antibody [NB300-190] - Rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~46 kDa gamma2-subunit of GABA A Receptor.
Immunohistochemistry: GABA-A R gamma 2 Antibody [NB300-190] - Immunostaining of mouse retina showing specific labeling of the GABAA 2 subunit in green, calbindin in red and DNA in blue
Western Blot: GABA-A R gamma 2 Antibody [NB300-190] - Rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~46k gamma2-subunit of GABAA -R.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ca, Ch, PmSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.15 mg/ml

Order Details

GABA-A R gamma 2 Antibody Summary

Immunogen
Fusion protein from the cytoplasmic loop of the gamma 2-subunit of rat GABAA receptor.
Specificity
Specific for the ~46k gamma2-subunit of the GABAA receptor in Western blots.
Predicted Species
Chicken (100%), Canine (100%), Primate (100%), Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GABRG2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:100
Application Notes
Use in Immunohistochemistry reported in scientific literature (PMID 25716832)
Theoretical MW
46 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NB300-190 in the following applications:

  • IHC
    1 publication
  • WB
    6 publications

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 23922756) Human reactivity reported in scientific literature (PMID: 24668190)

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Concentration
0.15 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GABA-A R gamma 2 Antibody

  • CAE2
  • ECA2
  • GABA A R gamma 2
  • GABA(A) receptor subunit gamma-2
  • GABAAR gamma 2
  • GABAARg2
  • GABRG2
  • gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • gamma-aminobutyric acid receptor subunit gamma-2
  • GEFSP3

Background

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GABA-A R gamma 2 Antibody (NB300-190)(8)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: IHC, WB.


Filter By Application
IHC
(1)
WB
(6)
All Applications
Filter By Species
Human
(1)
Mouse
(4)
Rat
(2)
All Species
Showing Publications 1 - 8 of 8.
Publications using NB300-190 Applications Species
Huang S, Hokenson K, Bandyopadhyay S et al. Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex. J. Neurosci. 2015 Dec 02 [PMID: 26631472] (WB, Mouse) WB Mouse
Johnson AC, Nagle KJ, Tremble SM, Cipolla MJ. The Contribution of Normal Pregnancy to Eclampsia. PLoS ONE. 2015 Jul 29 [PMID: 26218425] (WB, Rat) WB Rat
Wu Z, Kim ER, Sun H et al. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding J. Neurosci. 2015 Feb 25 [PMID: 25716832] (IHC, Mouse) IHC Mouse
Fatemi SH, Reutiman TJ, Folsom TD et al. Downregulation of GABAA Receptor Protein Subunits alpha6, beta2, delta, epsilon, gamma2, theta, and p2 in Superior Frontal Cortex of Subjects with Autism. J Autism Dev Disord 2014 Mar 26 [PMID: 24668190] (WB, Human) WB Human
Carlson SL, O'Buckley TK, Thomas R et al. Altered GABAA Receptor Expression and Seizure Threshold Following Acute Ethanol Challenge in Mice Lacking the RIIbeta Subunit of PKA. Neurochem Res. 2013 Oct 9 [PMID: 24104609] (WB, Mouse) WB Mouse
Bleckert A, Parker ED, Kang Y, et al. Spatial Relationships between GABAergic and Glutamatergic Synapses on the Dendrites of Distinct Types of Mouse Retinal Ganglion Cells across Development. PLoS One 2013 Jul 26 [PMID: 23922756] (WB, Mouse) WB Mouse
Joshi S, Sun C, Kapur J. A mouse monoclonal antibody against the gamma2 subunit of GABAA receptors. Hybridoma (Larchmt) 2011 Dec [PMID: 22149279]
Kharlamov EA, Lepsveridze E, Meparishvili M et al. Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy. Epilepsy Res;95(1-2):20-34. 2011 Jun. [PMID: 21439793] (WB, Rat) WB Rat

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for GABA-A R gamma 2 Antibody (NB300-190). (Showing 1 - 1 of 1 FAQs).

  1. I am looking for a "Primary antibody for GABAa receptor gamma 2" raised from antigen whose aa sequence is between exon 5-10. The application will be for "Immunohistochemistry". I would like to know if you have a product to match it?
    • NB300-190 is direceted against GABA A receptor gamma 2, is suitable for use in IHC and uses a fusion protein from the cytoplasmic loop of the gamma 2 subunit as an antigen, so this should suit your needs.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol GABRG2
Entrez
Uniprot