GABA-B R2 Antibody [Unconjugated] - N-Terminus

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GABAB R2 was detected in perfusion fixed frozen sections of rat spinal cord using Goat Anti-Rat GABAB R2 N-Terminus Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1188) at 15 µg/mL for 1 hour at ...read more

Product Details

Summary
Reactivity RtSpecies Glossary
Applications WB, Simple Western, IHC
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price

GABA-B R2 Antibody [Unconjugated] - N-Terminus Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant rat GABAB R2
Trp41-Ser482 (Phe337Tyr)
Accession # O88871
Specificity
Detects rat GABAB R2 N-Terminus in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
GABBR2
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-15 ug/mL
  • Simple Western 20 ug/mL
  • Western Blot 0.1 ug/mL
Publications
Read Publication using
AF1188 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GABA-B R2 Antibody [Unconjugated] - N-Terminus

  • G protein-coupled receptor 51
  • GABA B R2
  • GABABR2
  • GABA-BR2
  • GABA-B-R2
  • GABABR2GABA-B receptor 2
  • GABBR2
  • gamma-aminobutyric acid (GABA) B receptor, 2
  • gamma-aminobutyric acid type B receptor subunit 2
  • gb2
  • GPR51
  • GPR51GABA-B receptor, R2 subunit
  • GPRC3B
  • GPRC3BFLJ36928
  • G-protein coupled receptor 51
  • HG20HRIHFB2099

Background

GABBR2 is half of a heterodimeric GPCR for GABA which mediates coupling to G proteins. B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase As a homodimer, GABBR2 is retained in the endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment.  When GBR1/GBR2 heterodimers are present they are localized to the plasma membrane. GABBR2 is differentially expressed in the nervous system. GABBR2 and GABBR1 mRNA's are coexpressed in various brain regions such as the Purkinje cell layer of the cerebellum. In situ hybridization histochemistry using an antisensce probe to this novel receptor indicates GABBR2 is found exclusively in neurons. GABBR2 is implicated in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation and nociception.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GABA-B R2 Antibody (AF1188)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: Western Blot.


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Bioinformatics

Gene Symbol GABBR2
Uniprot