FE65 Antibody (SR1014) - BSA Free

Western Blot: FE65 Antibody (SR1014) [NBP3-22195] - Western blot analysis using NBP3-22195 in SH-SY5Y cell lysate.

• Reactivity: Hu
• Applications: WB, ICC/IF, IHC
• Clone: SR1014
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

FE65 Antibody (SR1014) - BSA Free Summary

• Description: Novus Biologicals Rabbit FE65 Antibody (SR1014) - BSA Free (NBP3-22195) is a recombinant monoclonal antibody validated for use in IHC, WB and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthesized peptide derived from human FE65 (Uniprot #: O00213)
• Specificity: Detects endogenous levels of total FE65
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: APBB1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Western Blot 1:500-1:2000
• Theoretical MW: 100 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.4, 150mM NaCl, 50% glycerol.
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for FE65 Antibody (SR1014) - BSA Free

• adaptor protein FE65a2
• amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
• amyloid beta A4 precursor protein-binding, family B, member 1
• Fe65
• FE65amyloid beta A4 precursor protein-binding family B member 1
• MGC:9072
• Protein Fe65
• RIR
• stat-like protein

Background

Amyloid beta A4 precursor protein-binding family B member 1, also known as FE65, is a signaling adaptor of APP protein. The FE65/APP complex has been shown to translocate into the cell nucleus and regulate gene expression, indicating that FE65 may be critical in the pathogenesis of Alzheimer's disease. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer's Disease patients.

FE65 antibodies are useful tools for research on Alzheimer's disease progression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: APBB1