APLP‑1 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Goat Anti-Human APLP‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3129) at ...read more
Simple Western lane view shows lysates of human brain (hippocampus) and mouse brain (hippocampus), loaded at 0.2 mg/mL. A specific band was detected for APLP‑1 at approximately 119 kDa (as indicated) using 25 ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for APLP-1 Antibody [Unconjugated]
amyloid beta (A4) precursor-like protein 1
amyloid precursor-like protein 1
amyloid-like protein 1
APLP-1 is a transmembrane metalloprotein that is expressed in central
neurons. Similar to APP and APLP-2, APLP-1 is susceptible to cleavage
by various secretases, generating multiple fragments from the
extracellular and intracellular domains. These include peptides similar
to the amyloidogenic A beta peptides and a cytoplasmic fragment that
associates with Fe65 family proteins and functions as a transcriptional
activator. The extracellular domain contains heparin and collagen
binding regions and is 89% identical between human and mouse.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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