APLP-1 Antibody [Unconjugated]

• Reactivity: Hu
• Applications: WB, IHC, IP
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

APLP-1 Antibody [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human APLP-1
  Gln34-Glu580
  Accession # P51693
• Specificity: Detects human APLP‑1 in Western blots. In Western blots, approximately 15% cross-reactivity with recombinant mouse APLP-1 is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: APLP1

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL
  • Immunohistochemistry 0.3-15 ug/mL
  • Immunoprecipitation 25 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for APLP-1 Antibody [Unconjugated]

• amyloid beta (A4) precursor-like protein 1
• amyloid precursor-like protein 1
• amyloid-like protein 1
• APLP1
• APLP-1
• APLPAPLP-1

Background

APLP-1 is a transmembrane metalloprotein that is expressed in central neurons. Similar to APP and APLP-2, APLP-1 is susceptible to cleavage by various secretases, generating multiple fragments from the extracellular and intracellular domains. These include peptides similar to the amyloidogenic A beta peptides and a cytoplasmic fragment that associates with Fe65 family proteins and functions as a transcriptional activator. The extracellular domain contains heparin and collagen binding regions and is 89% identical between human and mouse.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for APLP-1 Antibody (AF3129)(1)

Publication using AF3129

• L Schauenbur, F Liebsch, M Eravci, MC Mayer, C Weise, G Multhaup APLP1 is endoproteolytically cleaved by ?-secretase without previous ectodomain shedding Sci Rep, 2018;8(1):1916. 2018 [PMID: 29382944] (Western Blot, Human)

Bioinformatics

• Gene Symbol: APLP1
• Uniprot:
  • P51693()