FACA/FANCA Antibody (SR1233) - BSA Free

Western Blot: FACA/FANCA Antibody (SR1233) [NBP3-22105] - Western blot analysis using NBP3-22105 in A431 cell lysate.

• Reactivity: Hu
• Applications: WB, IP
• Clone: SR1233
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

FACA/FANCA Antibody (SR1233) - BSA Free Summary

• Description: Novus Biologicals Rabbit FACA/FANCA Antibody (SR1233) - BSA Free (NBP3-22105) is a recombinant monoclonal antibody validated for use in WB and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthesized peptide derived from human FACA/FANCA (Uniprot #: O15360)
• Specificity: Detects endogenous levels of total FACA/FANCA
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: FANCA
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1:40
  • Western Blot 1:500-1:1000
• Theoretical MW: 163 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.4, 150mM NaCl, 50% glycerol.
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for FACA/FANCA Antibody (SR1233) - BSA Free

• FA
• FA1
• FAA
• FAAMGC75158
• FACA
• FACAFanconi anemia group A protein
• FAH
• FA-H
• FANCA
• FANCH
• Fanconi anemia, complementation group A
• Fanconi anemia, complementation group H
• Fanconi anemia, type 1
• Protein FACA

Background

FANCA (Fanconi anemia group A) protein is a DNA repair protein that may function as a cell cycle checkpoint or in postreplication repair. FANCA may also be important for the maintenance of chromosome stability and reparation of interstrand DNA cross linkages.

Defects in FANCA result in Fanconi Anemia, a genetically heterogeneous autosomal recessive disorder characterized by progressive pancytopenia, diverse congenital malformations, and a predisposition to develop malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair. At the cellular level FANCA defects cause a hypersensitivity to DNA-damaging agents, chromosomal instability, and defective DNA repair.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FANCA