SOX10 Antibody [Unconjugated]

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SOX10 was detected in immersion fixed BG01V human embryonic stem cells differentiated to neural crest stem cells using Goat Anti-Human SOX10 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2864) at 10 µg/mL ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Conjugate Size Price
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SOX10 Antibody [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human SOX10
Met1-Ala118
Accession # P56693
Specificity
Detects human SOX10 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SOX10
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Immunocytochemistry 5-15 ug/mL
Publications
Read Publications using
AF2864 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOX10 Antibody [Unconjugated]

  • DOM
  • MGC15649
  • PCWH
  • SOX10
  • SRY (sex determining region Y)-box 10
  • SRY-related HMG-box gene 10
  • transcription factor SOX-10
  • WS4
  • WS4C
  • WS4mouse, human homolog of

Background

SOX10 belongs to the SOX family of transcription factors with diverse roles during development. In the central nervous system (CNS), SOX10 is required for the terminal differentiation of oligodendrocytes and myelination. In the peripheral nervous system, SOX10 maintains pluripotency of neural crest stem cells and suppresses neuronal differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SOX10 Antibody (AF2864)(14)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 8 applications: ICC, IHC, IHC - Not specified, IHC Not Specified, IHC OCT-embedded, IHC-Fr, IP, Proximity Ligation Assay.


Filter By Application
ICC
(5)
IHC
(2)
IHC - Not specified
(1)
IHC Not Specified
(1)
IHC OCT-embedded
(1)
IHC-Fr
(2)
IP
(1)
Proximity Ligation Assay
(1)
All Applications
Filter By Species
Human
(4)
Mouse
(8)
Rat
(1)
All Species
Showing Publications 1 - 10 of 14. Show All 14 Publications.
Publications using AF2864 Applications Species
KD Abu-Bonsra, D Zhang, AR Bjorksten, M Dottori, DF Newgreen Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem�Cells Stem Cell Reports, 2017;0(0):. 2017 [PMID: 29233551] (ICC,, Human) ICC Human
SV Fazal, JA Gomez-Sanc, LJ Wagstaff, N Musner, G Otto, M Janz, R Mirsky, KR Jessen Graded elevation of c-Jun in Schwann cells in vivo: gene dosage determines effects on development, re-myelination, tumorigenesis and hypomyelination J. Neurosci., 2017;0(0):. 2017 [PMID: 29109239] (IHC-Fr,, Mouse) IHC-Fr Mouse
T Mori, A Sukeda, S Sekine, S Shibata, E Ryo, H Okano, S Suzuki, N Hiraoka SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas Invest. Ophthalmol. Vis. Sci., 2017;58(12):5445-5451. 2017 [PMID: 29059311] (IHC-Fr,, Mouse) IHC-Fr Mouse
G Figlia, C Norrmén, JA Pereira, D Gerber, U Suter Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system Elife, 2017;6(0):. 2017 [PMID: 28880149] (IHC,, Mouse) IHC Mouse
Nevin Z, Factor D, Karl R, Douvaras P, Laukka J, Windrem M, Goldman S, Fossati V, Hobson G, Tesar P Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes. Am J Hum Genet, 0;100(4):617-634. 0 [PMID: 28366443] (ICC,, Human) ICC Human
ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes Am. J. Hum. Genet., 2017;100(4):617-634. 2017 [PMID: 28366443] (ICC, ) ICC
Yannick Poitelon YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells Nat Neurosci, 2016;0(0):. 2016 [PMID: 27273766] (IP,, Rat) IP Rat
A Blokzijl, LE Chen, SM Gustafsdot, J Vuu, G Ullenhag, O Kämpe, U Landegren, M Kamali-Mog, H Hedstrand Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay PLoS ONE, 2016;11(4):e0154214. 2016 [PMID: 27110718] (Proximity Ligation Assay,, Human) Proximity Ligation Assay Human
Najm F, Madhavan M, Zaremba A, Shick E, Karl R, Factor D, Miller T, Nevin Z, Kantor C, Sargent A, Quick K, Schlatzer D, Tang H, Papoian R, Brimacombe K, Shen M, Boxer M, Jadhav A, Robinson A, Podojil J, Miller S, Miller R, Tesar P Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature, 2015;522(7555):216-20. 2015 [PMID: 25896324] (IHC Not Specified,, Human) IHC Not Specified Human
Zou H, Feng R, Huang Y, Tripodi J, Najfeld V, Tsankova N, Jahanshahi M, Olson L, Soriano P, Friedel R Double minute amplification of mutant PDGF receptor alpha in a mouse glioma model. Sci Rep, 2015;5(0):8468. 2015 [PMID: 25683249] (IHC - Not specified,, Mouse) IHC - Not specified Mouse
Show All 14 Publications.

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Bioinformatics

Gene Symbol SOX10
Entrez
Uniprot