SOX10 Antibody [Unconjugated]

SOX10 was detected in immersion fixed SK‑Mel‑28 human malignant melanoma cell line using Goat Anti-Human SOX10 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2864) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Specific staining was localized to cell nuclei. Staining was performed using our protocol for Fluorescent ICC Staining of Non-adherent Cells.

SOX10 was detected in immersion fixed BG01V human embryonic stem cells differentiated to neural crest stem cells using Goat Anti-Human SOX10 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2864) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

SOX10 was detected in immersion fixed paraffin-embedded sections of human melanoma tissue using Goat Anti-Human SOX10 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2864) at 15 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell nuclei. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

PDGFR alpha driven brain tumors display features of high grade glioma.(a–g) Histopathological analysis of tumor areas by H&E staining shows a high concentration of mitotic figures (a, arrows), high cellularity and nuclear atypia (b), perineuronal satellitosis (c; N, neuronal nuclei), perivascular growth (d), intrafascicular growth (e), subarachnoid spreading (f), and areas of incipient necrosis (g; arrows point to pyknotic nuclei). (h–k) IF labeling of brain tumor sections for cell type specific markers. Nuclei labeled with DAPI are shown in blue. Tumor cells with high PDGFR alpha expression were highly proliferative, as seen by proliferation marker Ki67 (h), and express the OPC cell lineage markers Olig2, Sox2, Sox10, and Ng2, as well as the neural stem cell marker Nestin (i–k). Tumor cells were negative for immunosignal of astroglial marker GFAP, mature oligodendrocyte marker APC-CC1, and neuronal marker NeuN (l–n). Scale bars: 10 μm (a–g), 20 μm (h–n). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25683249), licensed under a CC-BY license. Not internally tested by R&D Systems.

Adult dynamin 2-depleted Schwann cells are replaced by dynamin 2-positive Schwann cells in remyelinated nerves.(A) Immunostainings for DNM2, SOX10 (SCs) and YFP (reporter-recombined SCs) on SN cross-sections of control* (MpzCreERT2:Rosa26-stoploxP/loxP-YFP) and P0ERT2-Dnm2KO* (MpzCreERT2:Dnm2loxP/loxP: Rosa26-stoploxP/loxP-YFP) mice at 4 wpT and 14 wpT. White arrows: YFP-recombined SCs that express DNM2 (in controls at 4 wpt and 14 wpt); black arrowheads: YFP-recombined SCs lacking DNM2 (in mutants at 4 wpt); white arrowheads: Non-recombined SCs expressing DNM2 (in controls and mutants at 4 wpt and 14 wpt). Scale bar = 25 μm for entire panel. (B) Quantification related to (A). Percentage of YFP+ cells among SOX10+ SCs/SN cross-sections at 4 wpT, 6 wpT, and 14 wpT. N = 3 mice/genotype, Two-Way ANOVA with Sidak’s multiple comparisons test. (C) Western blot analysis of cleaved caspase 3 (cC3) in SN lysates of control* and P0ERT2-Dnm2KO* mice at 4 wpT, 6 wpT and 14 wpT. Full-length blots in Supplementary file 1F. (D) Quantification referring to (C). Control average was set to 1. N = 3 mice/time point and genotype, Two-Way ANOVA with Sidak’s multiple comparisons test. Results in graphs represent means ±s.e.m.; ***p<0.001. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30648534), licensed under a CC-BY license. Not internally tested by R&D Systems.

Schwann cells lacking dynamin 2 show impaired cell cycle progression, reduced mitosis rate, and cytokinesis defects.(A) Schematic representation of the cell cycle phases marked by Ki-67 and EdU. (B) EdU-labeling, combined with immunostainings for Ki-67 and SOX10 on control and P0-Dnm2KO SN cross-sections at P5. Arrows: EdU+ Ki-67+ SOX10+ SCs, arrowheads: Ki-67+ SOX10+ SCs. Scale bar = 25 μm for entire panel. (C) Quantification of (B). Percentage of EdU+ SCs/SN cross-sections. N = 5 mice/time point and genotype, Two-Way ANOVA with Sidak’s multiple comparisons test. (D) Quantification of (B). Percentage of Ki-67+ SCs/SN cross-sections at P5. N = 5 mice/genotype, two-tailed unpaired Student´s t-test. (E) Quantification of (B). Percentage of EdU+ among Ki-67+ SCs/SN cross-section at P5. N = 5 mice/genotype, two-tailed unpaired Student´s t-test. (F) Quantification of mitotic events in cultured mouse SCs isolated from MpzCre:Rosa26-stoploxP/loxP-YFP (control*) and MpzCre:Dnm2loxP/loxP:Rosa26-stoploxP/loxP-YFP (P0-Dnm2KO*) SNs at P1, monitored by time-lapse microscopy for 24 hr. Each data point represents one individual animal (at least 42 cells/animal analyzed). N = 5 controls and seven mutant mice, two-tailed unpaired Student´s t-test. (G) Quantification of mitosis duration (minutes) of SCs of control* and P0-Dnm2KO* mice, monitored by time-lapse microscopy for 24 hr. Each data point represents one cell derived from a total of 5 control and seven mutant mice. Cells derived from each animal were isolated and analyzed separately, but pooled in one graph; two-tailed unpaired Student´s t-test. (H) Exemplary picture of a multinucleated Dnm2KO SCs after 48 hr in culture. Scale bar = 25 μm. (I) Quantification of multinucleated cells in control and Dnm2KO SCs after 24 hr, 48 hr and 76 hr in culture. N = 6 mice/genotype for 48 hr; N = 6 control* and n = 5 P0-Dnm2KO* mice for 24 hr and 72 hr, two-Way ANOVA with Sidak’s multiple comparisons test. (J) Exemplary time-lapse images of the mitosis of control and Dnm2KO SCs (YFP+ cells). Arrowheads: cell body of dividing SCs, black arrows: cytokinesis site. (K) Representative time-lapse images of Dnm2KO SC (YFP+) failing cytokinesis. The SC is undergoing mitosis, but fails to divide (arrowheads point to the cell body). Results in graphs represent means ±s.e.m.; *p<0.05, ***p<0.001. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30648534), licensed under a CC-BY license. Not internally tested by R&D Systems.

PDGFR alpha driven brain tumors display features of high grade glioma.(a–g) Histopathological analysis of tumor areas by H&E staining shows a high concentration of mitotic figures (a, arrows), high cellularity and nuclear atypia (b), perineuronal satellitosis (c; N, neuronal nuclei), perivascular growth (d), intrafascicular growth (e), subarachnoid spreading (f), and areas of incipient necrosis (g; arrows point to pyknotic nuclei). (h–k) IF labeling of brain tumor sections for cell type specific markers. Nuclei labeled with DAPI are shown in blue. Tumor cells with high PDGFR alpha expression were highly proliferative, as seen by proliferation marker Ki67 (h), and express the OPC cell lineage markers Olig2, Sox2, Sox10, and Ng2, as well as the neural stem cell marker Nestin (i–k). Tumor cells were negative for immunosignal of astroglial marker GFAP, mature oligodendrocyte marker APC-CC1, and neuronal marker NeuN (l–n). Scale bars: 10 μm (a–g), 20 μm (h–n). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25683249), licensed under a CC-BY license. Not internally tested by R&D Systems.

Filamentous actin is increased in Nedd4 knockdown&Nedd4−/− NCCs. e Representative images of migrating trunk NCCs within somites (S) 8–10 in control&Wnt1-Cre; Nedd4fl/fl E9.5 embryos. Whole embryos with 20–23 somites stained with anti-SOX10 (green)&anti-CD31 antibodies (red) to recognise NCCs&blood vessels. Dashed line marks the ventral limit of the dorsal aorta (DA) which was used to normalise migration distance of pioneering NCCs (arrowhead). Scale bar = 100 μm. Image collected & cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/35440627), licensed under a CC-BY license. Not internally tested by R&D Systems.

Mice lacking dynamin 2 in Schwann cells display characteristics of inflammation and Schwann cell death. (E) (Left) Immunostainings of controls and P0-Dnm2KO SN cross-sections for cleaved-caspase 3 (cC3) in combination with the SC marker SOX10 at P5. (Right) Percentage of cC3+ SOX10+ SCs at P5 and P14. N = 5 mice/time point and genotype, two-tailed unpaired Student’s t-test. Scale bar = 25 μm for entire panel. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/30648534), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Hu
• Applications: WB, IHC, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

SOX10 Antibody [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant human SOX10
  Met1-Ala118
  Accession # P56693
• Specificity: Detects human SOX10 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SOX10
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry 5-15 ug/mL
  • Immunohistochemistry 5-15 ug/mL
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOX10 Antibody [Unconjugated]

• DOM
• MGC15649
• PCWH
• SOX10
• SRY (sex determining region Y)-box 10
• SRY-related HMG-box gene 10
• transcription factor SOX-10
• WS4
• WS4C
• WS4mouse, human homolog of

Background

SOX10 belongs to the SOX family of transcription factors with diverse roles during development. In the central nervous system (CNS), SOX10 is required for the terminal differentiation of oligodendrocytes and myelination. In the peripheral nervous system, SOX10 maintains pluripotency of neural crest stem cells and suppresses neuronal differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SOX10 Antibody (AF2864)(122)

Publications using AF2864

• Titiz, M;Landini, L;Souza Monteiro de Araujo, D;Marini, M;Seravalli, V;Chieca, M;Pensieri, P;Montini, M;De Siena, G;Pasquini, B;Vannuccini, S;Iannone, LF;Cunha, TM;Brancolini, G;Bellantoni, E;Scuffi, I;Mastricci, A;Tesi, M;Di Tommaso, M;Petraglia, F;Geppetti, P;Nassini, R;De Logu, F; Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis Nature communications 2024-11-25 [PMID: 39587068] (Immunohistochemistry, Mouse, Transgenic Mouse)
• Nakatsuka, N;Adler, D;Jiang, L;Hartman, A;Cheng, E;Klann, E;Satija, R; A Reproducibility Focused Meta-Analysis Method for Single-Cell Transcriptomic Case-Control Studies Uncovers Robust Differentially Expressed Genes bioRxiv : the preprint server for biology 2024-10-16 [PMID: 39463993] (Immunohistochemistry, Transgenic Mouse)
• Li, J;Yang, F;Tian, Y;Wang, Z;Qi, D;Yang, Z;Song, J;Ding, J;Wang, X;Zhang, Z; Lateral/caudal ganglionic eminence makes limited contribution to cortical oligodendrocytes eLife 2024-09-11 [PMID: 39259197] (Immunohistochemistry, Mouse)
• Wang, L;Wang, C;Moriano, JA;Chen, S;Zuo, G;Cebrián-Silla, A;Zhang, S;Mukhtar, T;Wang, S;Song, M;de Oliveira, LG;Bi, Q;Augustin, JJ;Ge, X;Paredes, MF;Huang, EJ;Alvarez-Buylla, A;Duan, X;Li, J;Kriegstein, AR; Molecular and cellular dynamics of the developing human neocortex at single-cell resolution bioRxiv : the preprint server for biology 2024-08-04 [PMID: 39131371] (Immunohistochemistry, Xenograft)
• van Baarle, L;De Simone, V;Schneider, L;Santhosh, S;Abdurahiman, S;Biscu, F;Schneider, R;Zanoletti, L;Siqueira de Mello, R;Verbandt, S;Hu, Z;Stakenborg, M;Ke, BJ;Stakenborg, N;Salvador Laureano, R;García-Reyes, B;Henn, J;Toma, M;Vanmechelen, M;Boeckxstaens, G;De Smet, F;Garg, AD;Ibiza, S;Tejpar, S;Wehner, S;Matteoli, G; IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer Nature communications 2024-07-19 [PMID: 39030280] (Immunohistochemistry, Mouse)
• Verstraelen, P;Van Remoortel, S;De Loose, N;Verboven, R;Garcia-Diaz Barriga, G;Christmann, A;Gries, M;Bessho, S;Li, J;Guerra, C;Tükel, Ç;Ibiza Martinez, S;Schäfer, KH;Timmermans, JP;De Vos, WH; Serum amyloid A3 fuels a feed-forward inflammatory response to the bacterial amyloid curli in the enteric nervous system Cellular and molecular gastroenterology and hepatology 2024-03-29 [PMID: 38556049] (Immunocytochemistry, Human)
• Tsartsalis, S;Sleven, H;Fancy, N;Wessely, F;Smith, AM;Willumsen, N;Cheung, TKD;Rokicki, MJ;Chau, V;Ifie, E;Khozoie, C;Ansorge, O;Yang, X;Jenkyns, MH;Davey, K;McGarry, A;Muirhead, RCJ;Debette, S;Jackson, JS;Montagne, A;Owen, DR;Miners, JS;Love, S;Webber, C;Cader, MZ;Matthews, PM; A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease Nature communications 2024-03-12 [PMID: 38472200] (Flow Cytometry, Human)
• Gruel, R;Bijnens, B;Van Den Daele, J;Thys, S;Willems, R;Wuyts, D;Van Dam, D;Verstraelen, P;Verboven, R;Roels, J;Vandamme, N;Mancuso, R;Pita-Almenar, JD;De Vos, WH; S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging mice Aging cell 2024-05-01 [PMID: 38403918] (Immunohistochemistry, Mouse)
• Mak, S;Hammes, A; Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development International Journal of Molecular Sciences 2024-01-24 [PMID: 38338705] (Immunocytochemistry, Mouse)
• Robinson, BG;Oster, BA;Robertson, K;Kaltschmidt, JA; Loss of ASD-related molecule Cntnap2 affects colonic motility in mice Frontiers in neuroscience 2023-11-09 [PMID: 38027494] (Immunohistochemistry, Transgenic Mouse)
• Guo, R;Han, D;Song, X;Gao, Y;Li, Z;Li, X;Yang, Z;Xu, Z; Context-dependent regulation of Notch signaling in glial development and tumorigenesis Science advances 2023-11-10 [PMID: 37948517] (IHC, Mouse)
• Li J, Jaiswal MK, Chien JF et al. Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation Nat Commun 2023-09-15 [PMID: 37714849]
• Frazel, PW;Labib, D;Fisher, T;Brosh, R;Pirianian, N;Marchildon, A;Boeke, JD;Fossati, V;Liddelow, SA; Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols Nature neuroscience 2023-09-11 [PMID: 37697111] (ICC, Human)
• Clayton, BLL;Barbar, L;Sapar, M;Rusielewicz, T;Kalpana, K;Migliori, B;NYSCF Global Stem Cell Array® Team, ;Paull, D;Brenner, K;Moroziewicz, D;Sand, IK;Casaccia, P;Tesar, PJ;Fossati, V; Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis bioRxiv : the preprint server for biology 2023-08-02 [PMID: 37577713] (ICC, Human)
• Zhenqing Liu, Jianfei Chao, Cheng Wang, Guihua Sun, Daniel Roeth, Wei Liu et al. Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model Cell Reports 2023-08-29 [PMID: 37494190]
• Werner, L;Gliem, M;Rychlik, N;Pavic, G;Reiche, L;Kirchhoff, F;Silva Oliveira Junior, M;Gruchot, J;Meuth, SG;Küry, P;Göttle, P; A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage International journal of molecular sciences 2023-06-30 [PMID: 37446147] (IHC, Rat)
• Scavuzzo MA, Letai KC, Maeno-Hikichi Y et al. Enteric glial hub cells coordinate intestinal motility bioRxiv : the preprint server for biology 2023-06-09 [PMID: 37333182]
• Seixas, AI;Morais, MRG;Brakebusch, C;Relvas, JB; A RhoA-mediated biomechanical response in Schwann cells modulates peripheral nerve myelination Progress in neurobiology 2023-06-12 [PMID: 37315917] (Western Blot, Mouse)
• Huang, Z;Lin, J;Jiang, H;Lin, W;Huang, Z;Chen, J;Xiao, W;Lin, Q;Wang, J;Wen, S;Zhu, Q;Liu, J; Metformin promotes Schwann cell remyelination, preserves neural tissue and improves functional recovery after spinal cord injury Neuropeptides 2023-05-19 [PMID: 37236132] (IHC, Mouse)
• BG Robinson, BA Oster, K Robertson, JA Kaltschmid Loss of ASD-Related Molecule Caspr2 Affects Colonic Motility in Mice bioRxiv : the preprint server for biology, 2023-04-19;0(0):. 4/19/2023 [PMID: 37131706]
• SV Fazal, C Mutschler, CZ Chen, M Turmaine, CY Chen, YP Hsueh, A Ibañez-Gra, A Loreto, A Casillas-B, H Cabedo, RJM Franklin, RA Barker, KR Monk, BJ Steventon, MP Coleman, JA Gomez-Sanc, P Arthur-Far SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice Frontiers in Cellular Neuroscience, 2023-04-05;17(0):1158388. 2023-04-05 [PMID: 37091921] (ICC, Mouse)
• Anna F. Rockel, Nicole Wagner, Peter Spenger, Süleyman Ergün, Philipp Wörsdörfer Neuro-mesodermal assembloids recapitulate aspects of peripheral nervous system development in vitro Stem Cell Reports 2023-05-09 [PMID: 37084722]
• Yao Lulu Xing, Jasmine Poh, Bernard H.A. Chuang, Kaveh Moradi, Stanislaw Mitew, William D. Richardson et al. High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS Cell Reports Methods 2023-02-27 [PMID: 36936074]
• Y Chen, C Wu, S Peng, D Guo, H Ouyang, Y Wei, R Ju, X Ding, Z Xie, C Liu Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV) Investigative Ophthalmology & Visual Science, 2023-03-01;64(3):8. 2023-03-01 [PMID: 36867129] (IHC, Mouse)
• Weifeng Li, Cynthia Berlinicke, Yinyin Huang, Stefanie Giera, Anna G. McGrath, Weixiang Fang et al. High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells iScience 3/17/2023 [PMID: 36852281]
• EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar Pervasive environmental chemicals impair oligodendrocyte development bioRxiv : the preprint server for biology, 2023-02-12;0(0):. 2023-02-12 [PMID: 36798415] (IHC, Human)
• S Buller, S Kohnke, R Hansford, T Shimizu, WD Richardson, C Blouet Median eminence myelin continuously turns over in adult mice Molecular Metabolism, 2023-02-04;69(0):101690. 2/4/2023 [PMID: 36739968]
• Z Li, K Chen, Q Shao, H Lu, X Zhang, Y Pu, X Sun, H He, L Cao Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress Journal of Neuroinflammation, 2023-01-30;20(1):16. 2023-01-30 [PMID: 36710351] (ICC, IHC, Mouse)
• Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner et al. Teriflunomide as a therapeutic means for myelin repair Journal of Neuroinflammation 2023-01-07 [PMID: 36611185]
• Marion J. F. Levy, Beatriz Garcia-Diaz, Frédéric Sedel, Anne Baron-Van Evercooren, Sabah Mozafari High Dose Pharmaceutical Grade Biotin (MD1003) Accelerates Differentiation of Murine and Grafted Human Oligodendrocyte Progenitor Cells In Vivo International Journal of Molecular Sciences 2022-12-12 [PMID: 36555377]
• C Galante, N Marichal, FF Scarante, LM Ghayad, Y Shi, C Schuurmans, B Berninger, S Péron Enhanced proliferation of oligodendrocyte progenitor cells following retrovirus mediated Achaete-scute complex-like 1 overexpression in the postnatal cerebral cortex in vivo Frontiers in Neuroscience, 2022-12-02;16(0):919462. 2022-12-02 [PMID: 36532282] (IHC, Mouse)
• Zhao XF, Huffman LD, Hafner H et al. The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration eLife 2022-12-14 [PMID: 36515985]
• Waseem K. Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Kenneth J. Rhodes et al. Patient-derived three-dimensional cortical neurospheres to model Parkinson’s disease PLOS ONE 2022-12-01 [PMID: 36454869]
• Ideno H, Imaizumi K, Shimada H, Sanosaka T, Nemoto A, Kohyama J, Okano H Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms. iScience, 2022-09-16;25(10):105140. 2022-09-16 [PMID: 36185382] (IHC, Human)
• P Karras; I Bordeu; J Pozniak; A Nowosad; C Pazzi; N Van Raemdo; E Landeloos; Y Van Herck; D Pedri; G Bervoets; S Makhzami; JH Khoo; B Pavie; J Lamote; O Marin-Beja; M Dewaele; H Liang; X Zhang; Y Hua; J Wouters; R Browaeys; G Bergers; Y Saeys; F Bosisio; J van den Oo; D Lambrechts; AK Rustgi; O Bechter; C Blanpain; BD Simons; F Rambow; JC Marine A cellular hierarchy in melanoma uncouples growth and metastasis Nature 2022-09-21 [PMID: 36131018] (Immunohistochemistry, Human)
• Aurelia A Mapps; Erica Boehm; Corinne Beier; William T Keenan; Jennifer Langel; Michael Liu et al. Satellite glia modulate sympathetic neuron survival, activity, and autonomic function eLife 2022-08-23 [PMID: 35997251] (Immunohistochemistry, Transgenic Mouse)
• Maria Eleni Kastriti, Louis Faure, Dorothea Von Ahsen, Thibault Gerald Bouderlique, Johan Boström, Tatiana Solovieva et al. Schwann cell precursors represent a neural crest‐like state with biased multipotency The EMBO Journal 2022-09-01 [PMID: 35815410]
• X Hu, N Agarwal, MD Zhang, P Ernfors, R Kuner, JR Nyengaard, P Karlsson Identification and quantification of nociceptive Schwann cells in mice with and without Streptozotocin-induced diabetes Journal of chemical neuroanatomy, 2022-06-06;0(0):102118. 2022-06-06 [PMID: 35680105] (IHC, Mouse)
• P Kameneva, VI Melnikova, ME Kastriti, A Kurtova, E Kryukov, A Murtazina, L Faure, I Poverennay, AV Artemov, TS Kalinina, NV Kudryashov, M Bader, J Skoda, P Chlapek, L Curylova, L Sourada, J Neradil, M Tesarova, M Pasqualett, P Gaspar, VD Yakushov, BI Sheftel, T Zikmund, J Kaiser, K Fried, N Alenina, EE Voronezhsk, I Adameyko Serotonin limits generation of chromaffin cells during adrenal organ development Nature Communications, 2022-05-25;13(1):2901. 2022-05-25 [PMID: 35614045] (IHC, Rat)
• FM Piccolo, NR Kastan, T Haremaki, Q Tian, TL Laundos, R De Santis, AJ Beaudoin, TS Carroll, JD Luo, K Gnedeva, F Etoc, AJ Hudspeth, AH Brivanlou Role of YAP in early ectodermal specification and a Huntington&#039;s Disease model of human neurulation Elife, 2022-04-22;11(0):. 2022-04-22 [PMID: 35451959] (ICC/IF, Human)
• Luipa Khandker, Marisa A. Jeffries, Yun-Juan Chang, Marie L. Mather, Angelina V. Evangelou, Jennifer N. Bourne et al. Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord Cell Reports 2022-03-01 [PMID: 35235799]
• Alwyn Dady, Lindsay Davidson, Pamela A Halley, Kate G Storey Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments eLife 2022-02-21 [PMID: 35188104]
• Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco, Juana Gallar et al. A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair eLife 2022-01-25 [PMID: 35076395]
• Justine D. Manos, Christina N. Preiss, Nandini Venkat, Joseph Tamm, Peter Reinhardt, Taekyung Kwon et al. Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model iScience 2022-01-21 [PMID: 35072001]
• KG Zyner, A Simeone, SM Flynn, C Doyle, G Marsico, S Adhikari, G Portella, D Tannahill, S Balasubram G-quadruplex DNA structures in human stem cells and differentiation Nature Communications, 2022-01-10;13(1):142. 2022-01-10 [PMID: 35013231] (ICC, Human)
• Kelly F. Paton, Katharina Robichon, Nikki Templeton, Lisa Denny, Afnan Al Abadey, Dan Luo et al. The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis Frontiers in Neurology 2021-12-20 [PMID: 34987466] (Immunohistochemistry, Mouse)
• Li R, Walsh P, Truong V et al. Differentiation of Human iPS Cells Into Sensory Neurons Exhibits Developmental Stage-Specific Cryopreservation Challenges Frontiers in Cell and Developmental Biology 2021-12-14 [PMID: 34970550]
• Fan Wang, Xiao-Ru Ma, Yang Wu, Yong-Cheng Xu, Hui-Min Gu, Di-Xian Wang et al. Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain Frontiers in Cellular Neuroscience 2021-10-22 [PMID: 34744634]
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Reviews for SOX10 Antibody (AF2864) (2)

Average Rating: 5

(Based on 2 reviews)

We have 2 reviews tested in 1 species: Mouse.

reviewed by: Verified Customer IHC-Fr Mouse 05/09/2019

Summary

• Application: Immunohistochemistry-Frozen
• Sample Tested: Embryonic spinal cord
• Species: Mouse
• Lot: VRY0516091

reviewed by: Kelli Jordan IHC-P Mouse 02/26/2019

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: Mouse Pancreas
• Species: Mouse
• Lot: VRY081810C

Comments

• Comments: Antigen retrieval: HIER, pH 6
  Block: 1 hour in 2% normal donkey serum, 2 mg/ml BSA; 0.2% triton-x
  Primary: 10 ug/ml in blocking buffer, overnight at 4C
  Secondary: Donkey anti-goat DyLight 650, 1:300 for 1 hour

Bioinformatics

• Gene Symbol: SOX10
• Uniprot:
  • P56693()