Dtk/TYRO3 Antibody - BSA Free

Immunohistochemistry-Paraffin: Dtk/TYRO3 Antibody [NBP2-23725] - Analysis of TYRO3 in paraffin-embedded formalin-fixed human liver tissue using an isotype control (top) and this antibody (bottom) at 1:100.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Dtk/TYRO3 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit Dtk/TYRO3 Antibody - BSA Free (NBP2-23725) is a polyclonal antibody validated for use in IHC. Anti-Dtk/TYRO3 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Within the range of amino acids 110-140 of human TYRO3 protein were used as the immunogen.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TYRO3
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1: 100

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: chicken (81%).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Whole sera with 50% Glycerol
• Preservative: 0.025% Sodium Azide
• Purity: Unpurified

Alternate Names for Dtk/TYRO3 Antibody - BSA Free

• Brt
• BYK
• Dtk
• EC 2.7.10
• EC 2.7.10.1
• FLJ16467
• Rse
• Sky
• Tif
• TYRO3 protein tyrosine kinase
• Tyro3
• Tyrosine-protein kinase byk
• Tyrosine-protein kinase DTK
• tyrosine-protein kinase receptor TYRO3
• Tyrosine-protein kinase RSE
• Tyrosine-protein kinase SKY

Background

Receptor protein tyrosine kinases (RPTKs) are a class of transmembrane signaling molecules. They have been shown to regulate signaling cascades that control synaptic function in the central nervous system (CNS). Tyro3 is one of three RPTKs belonging to the Axl/UFO subfamily, that also includes Axl and Mer. Tyro3 is the most commonly expressed of these receptors in the CNS. It may be involved in the cell adhesion process, and is commonly found in adult tissues with expression mostly in brain, testis, vascular and lymphatic tissue.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Dtk/TYRO3 Antibody (NBP2-23725)(1)

Publication using NBP2-23725

• Alexander P B, Chen R et al. Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer. J Biol Chem 2017-01-13 [PMID: 27903634] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: TYRO3
• Uniprot:
  • Q06418()