DR3/TNFRSF25 Antibody Summary
Antibody was raised against a peptide corresponding to amino acids in extracellular domain (ED) of human DR3 precusor.
Ion exchange chromatography
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Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Ion exchange chromatography
DR3 antibody can be used for detection of DR3 expression by Western blot at 1:500 to 1:1000 dilution. 59 kDa band should be detected.
Alternate Names for DR3/TNFRSF25 Antibody
- Apoptosis-inducing receptor AIR
- Apoptosis-mediating receptor DR3
- Apoptosis-mediating receptor TRAMP
- Death receptor 3
- DR3member 12 (translocatingchain-association membrane protein)
- Lymphocyte-associated receptor of death
- Protein WSL
- Protein WSL-1
- tumor necrosis factor receptor superfamily, member 25
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kappaB activation.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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