Recombinant Mouse TL1A/TNFSF15 Protein


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Recombinant Mouse TL1A/TNFSF15 Protein Summary

Details of Functionality
Measured by its ability to induce apoptosis of TF‑1 human erythroleukemic cells. Migone, T. et al. (2002) Immunity 16:479. The ED50 for this effect is 15-75 ng/mL.
E. coli-derived mouse TL1A/TNFSF15 protein
Ile76-Leu252, with an N-terminal Met
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


  • Bioactivity
Theoretical MW
20 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using
1896-TL in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse TL1A/TNFSF15 Protein

  • MGC129934
  • MGC129935
  • TL1A
  • TL1Vascular endothelial cell growth inhibitor
  • TNF superfamily ligand TL1A
  • TNFSF15
  • tumor necrosis factor (ligand) superfamily, member 15
  • tumor necrosis factor ligand superfamily member 15
  • vascular endothelial growth inhibitor-192A
  • VEGI
  • VEGI192A
  • VEGITNF ligand-related molecule 1


TL1A is a type II transmembrane protein belonging to the TNF superfamily and has been designated TNF superfamily member 15 (TNFSF15). Mouse TL1A is a 252 amino acid residues (aa) protein consisting of a 35 aa N-terminal cytoplasmic domain, a 24 aa transmembrane region and 193 aa C-terminal extracellular domain (1). TL1A is expressed predominantly in endothelial cells and its expression is stimulated by TNF-a and IL-1a (1). Non-endothelial cells of the gut mucosa, including lamina propria lymphocytes and tissue macrophages, also express TL1A and at higher levels in chronic inflammatory bowel disorders (2). TL1A binds with high affinity to death receptor 3 (DR3), which is now designated TNF receptor superfamily member 25 (TNFRSF25). DR3 was formerly designated TNFRSF12 when it was thought to be the receptor for TWEAK/TNFSF12. Depending on the cell type, DR3-TL1A interactions have different effects. Ligation of DR3 on activated T cells by TL1A provides a costimulatory signal to increase IL-2 responsiveness and the secretion of proinflamatory cytokines (1). The promotion of survival of activated T cells by TL1a results from the activation of the transcription factor NF-kappa-B. In a tumor erythroleukemic cell line, TF-1, DR3-TL1A signaling increases production of the NF-kB-dependent antiapoptotic protein c-IAP2, promoting survival in these cells (3). In HUVEC cells, which express both DR3 and TL1A, ligation of DR3 by TL1A regulates cell apoptosis (4). These effects of TL1A are blocked by the secreted, soluble decoy receptor 3 (DcR3), also known as TR6 and TNFRSF6B, which compete with DR3 for binding to TL1A (1-4). Consistent with the observed in vitro activities, TL1A promotes ex vivo splenocyte expansion and enhances in vivo graft-versus-host-response. The level of TL1A in cells of gut mucosa, in patients with bowel inflammatory disorders, correlates with the severity of inflammation, and TL1A may play a role in a Th1-mediate pathological conditions such as Crohn’s disease (2). Mouse and human TL1A share 73% homology in their C-terminal domains.

  1. Migone, T.S. et al. (2002) Immunity 16:479.
  2. Bamias, G. et al. (2003) J. Immunol. 171:4868.
  3. Wen, L. et al. (2003) J. Biol. Chem. 278:39251.
  4. Yang, C.-R. et al. (2004) Cancer Res. 64:1122.

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Publications for TL1A/TNFSF15 (1896-TL)(16)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Bioassay, Cell Culture, ELISA (Standard), In Vivo.

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Showing Publications 1 - 10 of 16. Show All 16 Publications.
Publications using 1896-TL Applications Species
N Jacob, K Kumagai, JP Abraham, Y Shimodaira, Y Ye, J Luu, AY Blackwood, SL Castanon, DT Stamps, LS Thomas, R Gonsky, DQ Shih, KS Michelsen, SR Targan Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo Sci Rep, 2020-10-23;10(1):18189. 2020-10-23 [PMID: 33097818] (Cell Culture, Mouse) Cell Culture Mouse
N Jacob, JP Jacobs, K Kumagai, CWY Ha, Y Kanazawa, V Lagishetty, K Altmayer, AM Hamill, A Von Arx, RB Sartor, S Devkota, J Braun, KS Michelsen, SR Targan, DQ Shih Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome Mucosal Immunol, 2018-07-09;0(0):. 2018-07-09 [PMID: 29988118] (Bioassay, Mouse) Bioassay Mouse
JR Ferdinand, AC Richard, F Meylan, A Al-Shamkha, RM Siegel Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells J. Immunol., 2018-01-15;0(0):. 2018-01-15 [PMID: 29335258] (ELISA (Standard), Mouse) ELISA (Standard) Mouse
Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells Nat Commun, 2016-08-05;7(0):12368. 2016-08-05 [PMID: 27492902] (Bioassay, Mouse) Bioassay Mouse
Li-Guo Jia A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection J Immunol, 2016-05-27;197(1):377-86. 2016-05-27 [PMID: 27233964] (Bioassay, Mouse) Bioassay Mouse
P Holmkvist, L Pool, K Hägerbrand, WW Agace, A Rivollier IL-18R?-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness Eur J Immunol, 2016-05-06;0(0):. 2016-05-06 [PMID: 27062602] (Bioassay, Mouse) Bioassay Mouse
Gomez-Rodriguez J, Meylan F, Handon R, Hayes E, Anderson S, Kirby M, Siegel R, Schwartzberg P Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4. Nat Commun, 2016-03-03;7(0):10857. 2016-03-03 [PMID: 26936133] (Bioassay, Mouse) Bioassay Mouse
Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, Swaminath A, Bonneau R, Scherl E, Littman D CX(3)CR1(+) mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med, 2014-07-14;211(8):1571-83. 2014-07-14 [PMID: 25024136] (Bioassay, Mouse) Bioassay Mouse
Yu , X, Pappu , R, Ramirez-Carrozzi , V, Ota , N, Caplazi , P, Zhang , J, Yan , D, Xu , M, Lee , W P, Grogan , J L TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers. Mucosal Immunol, 2013-11-13;7(3):730-40. 2013-11-13 [PMID: 24220298] (Bioassay, In Vivo, Mouse) Bioassay, In Vivo Mouse
Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses. J Immunol, 2013-10-18;191(11):5420-9. 2013-10-18 [PMID: 24140642] (Bioassay, Mouse) Bioassay Mouse
Show All 16 Publications.

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Gene Symbol Tnfsf15