DR3/TNFRSF25 Products

Description

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family, through their death domain containing receptors TNFR1 and Fas. A cell surface receptor with a death domain, DR3, has been identified by several groups independently, although it has been given alternative names. The ligand for DR3 has very recently been identified as TWEAK, also termed Apo3L. DR3 is highly expressed in tissues enriched in lymphocytes including PBL, thymus and spleen. DR3 mediates activation of NF kappa B, and induces apoptosis. DR3 may also play a role in regulating lymphocyte homeostasis.

Bioinformatics

Entrez	8718 Human
Uniprot	NP_003781 Human AAQ88676 Human Q93038 Human
Product By Gene ID	8718
Alternate Names	Lymphocyte-associated receptor of death Protein WSL Death receptor 3 WSL1 Apoptosis-mediating receptor TRAMP WSL Apoptosis-mediating receptor DR3 Apo-3 Apoptosis-inducing receptor AIR APO3 DR3member 12 (translocatingchain-association membrane protein) Protein WSL-1 tumor necrosis factor receptor superfamily, member 25

Diseases related to DR3/TNFRSF25

Discover more about diseases related to DR3/TNFRSF25.

Neoplasms
Malignant Neoplasms
Prostatic Neoplasms
Malignant Neoplasm Of Prostate
Inflammation
Adenocarcinoma
Carcinoma
Neoplasm Metastasis
Autoimmune Reaction
Cell Transformation, Neoplastic
Rheumatoid Arthritis
Arthritis
Carcinogenesis
Intestinal Diseases
Lymphoma
Tissue Adhesions
Autoimmune Diseases
Tumor Angiogenesis
Inflammatory Bowel Diseases
Tumor Progression

Pathways for DR3/TNFRSF25

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Cell Death
Cell Proliferation
Secretion
Pathogenesis
Methylation
Cell Cycle
Angiogenesis
Localization
Dna Methylation
Programmed Cell Death
Induction Of Apoptosis
Cytokine Production
Cell Growth
Cell Activation
T Cell Activation
Immune Response
Cell Differentiation
T Cell Costimulation
Tissue Homeostasis
Anoikis

Research Areas for DR3/TNFRSF25

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Apoptosis
Cell Biology

PTMs for DR3/TNFRSF25

Learn more about PTMs related to DR3/TNFRSF25.

Phosphorylation
Cleavage
Methylation
Ubiquitination
Acetylation

Bioinformatics Tool for DR3/TNFRSF25

Discover related pathways, diseases and genes to DR3/TNFRSF25. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.