Species: Hu, Mu
Applications: WB, Flow, CyTOF-ready
Host: Mouse Monoclonal
Species: Mu
Applications: WB, IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: Binding Activity
Species: Mu
Applications: Binding Activity
Species: Hu
Applications: PAGE
Species: Hu
Applications: RNAi, RNAi SP
Species: Hu
Applications: RNAi, RNAi SP
Species: Hu
Applications: RNAi, RNAi SP
Description
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family, through their death domain containing receptors TNFR1 and Fas. A cell surface receptor with a death domain, DR3, has been identified by several groups independently, although it has been given alternative names. The ligand for DR3 has very recently been identified as TWEAK, also termed Apo3L. DR3 is highly expressed in tissues enriched in lymphocytes including PBL, thymus and spleen. DR3 mediates activation of NF kappa B, and induces apoptosis. DR3 may also play a role in regulating lymphocyte homeostasis.
Bioinformatics
Entrez |
Human |
Uniprot |
Human Human Human |
Product By Gene ID |
8718 |
Alternate Names |
- Lymphocyte-associated receptor of death
- Protein WSL
- Death receptor 3
- WSL1
- Apoptosis-mediating receptor TRAMP
- WSL
- Apoptosis-mediating receptor DR3
- Apo-3
- Apoptosis-inducing receptor AIR
- APO3
- DR3member 12 (translocatingchain-association membrane protein)
- Protein WSL-1
- tumor necrosis factor receptor superfamily, member 25
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Research Areas for DR3/TNFRSF25
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ApoptosisCell Biology
Bioinformatics Tool for DR3/TNFRSF25
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