DIO2 Antibody - BSA Free

Western Blot: DIO2 Antibody [NBP3-41877] - Sample: Lane1: Rat Brain Tissue; Lane2: Mouse Brain Tissue.

Western Blot: DIO2 Antibody [NBP3-41877] - Sample: Recombinant DIO2, Rat.

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 0.5 mg/ml

DIO2 Antibody - BSA Free Summary

• Immunogen: Immunized with recombinant Rat DIO2 (Uniprot#: P70551; Ser30-Phe259 (Uniprot#: P70551)
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DIO2
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.5-2ug/mL

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.01M PBS, pH7.4, 50% glycerol
• Preservative: 0.05% Proclin 300
• Concentration: 0.5 mg/ml
• Purity: Antigen and protein A Affinity-purified

Alternate Names for DIO2 Antibody - BSA Free

• 5DII
• D2
• deiodinase, iodothyronine, type II
• DIOII
• EC 1.97.1
• EC 1.97.1.10
• ITDI2
• SelY
• TXDI2thyroxine deiodinase, type II
• Type 2 DI
• type 2 iodothyronine deiodinase
• type II iodothyronine deiodinase
• type-II 5'deiodinase
• Type-II 5'-deiodinase

Background

DIO2 is encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DIO2