DIO2 Products

Antibodies
DIO2 Antibody
DIO2 Antibody
NBP1-00178
Species: Mu
Applications: WB, IHC, IHC-Fr, IHC-P, PEP-ELISA
Host: Goat Polyclonal
DIO2 Antibody
DIO2 Antibody
NBP2-56543
Species: Hu
Applications: ICC/IF
Host: Rabbit Polyclonal
Proteins
DIO2 Recombinant Protein Anti ...
DIO2 Recombinant Protein Antigen
NBP2-56543PEP
Species: Hu
Applications: B/N, Ctrl
Recombinant Human DIO2 Protei ...
Recombinant Human DIO2 Protein
H00001734-Q01
Species: Hu
Applications: WB, ELISA, PA

Description

DIO2 is encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 1734
Alternate Names
  • EC 1.97.1.10
  • EC 1.97.1
  • DIOII
  • ITDI2
  • 5DII
  • type-II 5'deiodinase
  • Type-II 5'-deiodinase
  • type II iodothyronine deiodinase
  • Type 2 DI
  • type 2 iodothyronine deiodinase
  • SelY
  • TXDI2thyroxine deiodinase, type II
  • D2
  • deiodinase, iodothyronine, type II

Bioinformatics Tool for DIO2

Discover related pathways, diseases and genes to DIO2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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