DIO2 Products

Description

DIO2 is encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Bioinformatics

Entrez	13371 Mouse 1734 Human 65162 Rat
Uniprot	NP_000784.2 Human NP_054644 Human Q92813 Human
Product By Gene ID	1734
Alternate Names	5DII D2 deiodinase, iodothyronine, type II DIOII EC 1.97.1 EC 1.97.1.10 ITDI2 SelY TXDI2thyroxine deiodinase, type II Type 2 DI type 2 iodothyronine deiodinase type II iodothyronine deiodinase type-II 5'deiodinase Type-II 5'-deiodinase