Western blot shows lysates of NCI‑H460 human large cell lung carcinoma cell line, human lung tissue, and human placenta tissue. PVDF membrane was probed with 0.25 µg/mL of Mouse Anti-Human Hematopoietic Prostaglandin ...read more
Hematopoietic Prostaglandin D Synthase/HPGDS was detected in immersion fixed HEL 92.1.7 human erythroleukemic cell line using Mouse Anti-Human Hematopoietic Prostaglandin D Synthase/HPGDS Monoclonal Antibody ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Sterile PBS to a final concentration of 0.5 mg/mL.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Hematopoietic Prostaglandin D Synthase/HPGDS Antibody (735301) [Unconjugated]
glutathione S-transferase sigma
Glutathione-dependent PGD synthase
Glutathione-requiring prostaglandin D synthase
GSTShematopoietic prostaglandin D2 synthase
hematopoietic prostaglandin D synthase
PGDSglutathione-dependent PGD synthetase
Prostaglandin D Synthase (PGDS) catalyzes the conversion of prostaglandin (PG) H2 to PGD2, which is a major prostanoid produced in a variety of tissues. Two types of PGDS have been isolated; the glutathione-dependent hematopoietic PGDS (HPGDS) and the glutathione-independent lipocalin‑type PGDS (1). HPGDS is a cytosolic enzyme that is expressed in mast cells and antigen presenting cells (2, 3). It is the only mammalian member of the class Sigma glutathione S‑transferase, showing a broad specificity towards standard transferase substrates (4). The PGD2 produced by HPGDS is involved in many physiological processes such as maintaining body temperature, promotion of sleep, inhibition of platelet aggregation and bronchoconstriction (5). It also functions in immune response and acts as a mediator in allergy and inflammation (6). HPGDS‑specific inhibitors may be therapeutically useful anti‑allergic and anti‑inflammatory drugs.
Urade, Y. and Eguchi, N. (2002) Prostaglandins Other Lipid Mediat. 68:375.
Urade, Y. et al. (1990) J. Biol. Chem. 265:371.
Urade, Y. et al. (1989) J. Immunol. 143:2982.
Jowsey, I. R. et al. (2001) Biochem. J. 359:507.
Kanaoka, Y. and Urade, Y. (2003) Prostaglandins Leukot. Essent. Fatty Acids 69:163.
Oguma, T. et al. (2008) Allergol. Int. 57:307.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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