Dectin-1/CLEC7A Antibody (BD6) [Alexa Fluor® 647]

Flow Cytometry: Mouse Monoclonal Dectin-1/CLEC7A Antibody (BD6) [Alexa Fluor® 647] [NBP1-21513AF647] - Detection of human Dectin1/CLEC7A on HEK cells expressing isoform A of human Dectin1/CLEC7A. The cells received 5 uL of the human Dectin1/CLEC7A AF647-conjugated antibody (BLUE) or mouse IgG2b AF647-conjugated isotype control (RED). Image from a verified customer review.

• Reactivity: Hu
• Applications: Flow
• Clone: BD6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Dectin-1/CLEC7A Antibody (BD6) [Alexa Fluor® 647] Summary

• Immunogen: NIH3T3 cells expressing full length Beta-glucan receptor
• Specificity: NBP1-21513 recognizes human Dectin-1, also known as beta-glucan receptor (betaGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (betaGR-A and betaGR-B) and several minor isoforms. betaGR-A and betaGR-B differs by the presence and absence, respectively, of a stalk region. Clone BD6 recognizes betaGR-A only.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: CLEC7A
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Dectin-1/CLEC7A Antibody (BD6) [Alexa Fluor® 647]

• Beta-glucan receptor
• BGR
• CD369
• CLEC7A
• CLECSF12
• CLECSF12DC-associated C-type lectin 1
• C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 12
• C-type lectin domain family 7 member A
• C-type lectin domain family 7, member A
• C-type lectin superfamily member 12
• Dectin1
• Dectin-1
• DECTIN1CANDF4
• Dendritic cell-associated C-type lectin 1
• dendritic cell-associated C-type lectin-1
• hDectin-1
• lectin-like receptor 1

Background

Dectin1 encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Review for Dectin-1/CLEC7A Antibody (NBP1-21513AF647) (1)

Average Rating: 5

(Based on 1 review)

We have 1 review tested in 1 species: Human.

reviewed by: Panagiotis Fotakis Flow Human 02/15/2024

Summary

• Application: Flow Cytometry
• Sample Tested: HEK expressing human Dectin1
• Species: Human
• Lot: 148808-010920-AF647

Bioinformatics

• Gene Symbol: CLEC7A