WB: Approx. 60 kDa band observed in human ovary lysates (calculated MW of 57.4 kDa band according to NP_000093.1). IHC-P: Human adenal gland shows strong granular staining of the cytoplasm in medulla cells.
Predicted cross-reactivity based on sequence identity: Feline, Canine.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for Cytochrome P450 17A1 Antibody
cytochrome p450 XVIIA1
cytochrome P450, family 17, subfamily A, polypeptide 1
cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenalhyperplasia
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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