CXCR3 Antibody - BSA Free

Western Blot: CXCR3 Antibody [NBP2-41250] - Analysis of CXCR3 in HepG2 lysate with CXCR3 antibody at (A) 1 and (B) 2 ug/ml.

Immunocytochemistry/Immunofluorescence: CXCR3 Antibody [NBP2-41250] - Immunocytochemistry of CXCR3 in HepG2 cells with CXCR3 antibody at 5 ug/mL.

Immunocytochemistry/ Immunofluorescence: CXCR3 Antibody - BSA Free [NBP2-41250] - Immunofluorescence of CXCR3 in HepG2 cells with CXCR3 antibody at 20 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

CXCR3 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit CXCR3 Antibody - BSA Free (NBP2-41250) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. Anti-CXCR3 Antibody: Cited in 4 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 19 amino acid peptide near the carboxy terminus of human CXCR3 . The immunogen is located within the last 50 amino acids of CXCR3. Amino Acid Squence: RGLQRQPSSSRRDSSWSET
• Specificity: At least two isoforms of CXCR3 are known to exist; this antibody will detect both isoforms.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CXCR3
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence 5 -20 ug/ml
  • Western Blot 1 - 2 ug/ml
• Theoretical MW: 43 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Goat (89%), Bovine (88%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for CXCR3 Antibody - BSA Free

• CD183 antigen
• CD183
• chemokine (C-X-C motif) receptor 3
• chemokine (C-X-C) receptor 3
• CKR-L2IP-10 receptor
• CMKAR3
• C-X-C chemokine receptor type 3
• CXCR3
• CXC-R3
• CXCR-3
• G protein-coupled receptor 9CD182
• GPR9
• GPR9Mig-R
• Interferon-inducible protein 10 receptor
• IP10 receptor
• IP10-R
• Mig receptor
• MigR

Background

CXCR3, a Chemokine Receptor, is highly similar to the interleukine 8B receptor and has been shown to mediate recruitment of T cells to sites of inflammation and retention of T-cells in the inflamed CNS. CXCR3 has been suggested to be the principal inflammatory chemokine receptor involved in intrathecal accumulation of T-cells in multiple sclerosis and diabetes. It is expressed on malignant B cells in chronic lymphoproliferative disorders (Jones et al., 2000). An alternatively spliced isoform, CXCR3B, has recently been identified (Lasagni et al. 2003). CXCR3 expression has been documented in the brain, lymphoid and other peripheral tissues, and in diseasess including atheroslerosis, Alzheimer's, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory conditions of various organs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CXCR3 Antibody (NBP2-41250)(4)

Publications using NBP2-41250

• Lim SW, Shin YJ, Cui S et al. Therapeutic effect of multiple functional minicircle vector encoding anti-CD25/IL-10/CXCR3 in allograft rejection model The Korean journal of internal medicine 2022-06-21 [PMID: 35725307] (ELISA)
• Petrisko TJ, Bloemer J, Pinky PD et al. Neuronal CXCL10/CXCR3 Axis Mediates the Induction of Cerebral Hyperexcitability by Peripheral Viral Challenge Front Neurosci 2020-03-24 [PMID: 32265633] (ICC/IF, Mouse)
• Mohammed S, Torres Luquis O, Walls E, Lloyd F. Lymph-Circulating Tumor Cells show distinct properties to Blood-Circulating Tumor Cells and constitute extraordinary efficient metastatic precursors Mol Oncol 2019-04-27 [PMID: 31026363]
• Piotrowska A, Rojewska E, Pawlik K et al. Pharmacological blockade of CXCR3 by NBI-74330 reduces neuropathic pain and enhances opioid effectiveness, evidence from in vivo and in vitro studies Biochim. Biophys. Acta 2018-08-01 [PMID: 30076959] (ICC/IF, Rat)

Bioinformatics

• Gene Symbol: CXCR3