CTLA-4 Antibody (WKH203) Summary
Purified rCTLA-4hIg fusion protein.
Type I membrane protein.
NB100-63254 recognizes rat CD152, also known as cytotoxic-T-lymphocyte antigen-4 (CTLA-4), which is similar in structure to CD28 and also binds ligands CD80 and CD86. CD152 is expressed by activated T-lymphocytes. Studies suggest that CD152 is also expressed by regulatory T-lymphocytes.
Protein G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Western Blot 1:100-1:2000
- ELISA 1:100-1:2000
- Flow Cytometry 1:10-1:20
Membrane permeabilisation is required for this application.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.09% Sodium Azide
Protein G purified
Alternate Names for CTLA-4 Antibody (WKH203)
- CD152 antigen
- celiac disease 3
- cytotoxic T-lymphocyte antigen 4
- cytotoxic T-lymphocyte protein 4
- Cytotoxic T-lymphocyte-associated antigen 4
- cytotoxic T-lymphocyte-associated protein 4
- cytotoxic T-lymphocyte-associated serine esterase-4
- ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
CTLA4 has a critical role in T cell differentiation and contributes to the maintenance of peripheral T cell tolerance to self antigens. It exerts its major effects on T cell immune responses via regulation of the cell cycle and may be involved in T cell activation. It binds to B7-1 (CD80) and B7-2 (CD86), and it contains one immunoglobulin-like V type domain. It is widely expressed, with highest levels in lymphoid tissues.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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