Recombinant Human CTGF/CCN2 Protein

Product Discontinued

Recombinant Human CTGF/CCN2 Protein Summary

• Description: A full-length recombinant protein corresponding to CTGF.

  Source: E. coli

  ( NCBI Accession #: NP_001892.)

• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: CCN2
• Purity: >95%, by HPLC
• Endotoxin Note: Endotoxin, tested

Applications/Dilutions

• Dilutions:
  • Functional
  • SDS-Page
• Application Notes: This protein is useful for Functional assays and SDS-Page
• Theoretical MW: 68 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized in buffer. Information about buffer components is properietary.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: >95%, by HPLC
• Reconstitution Instructions: Reconstitute with water to a final concentration of 0.1 - 1.0 mg/ml.

Alternate Names for Recombinant Human CTGF/CCN2 Protein

• CCN2IGFBP-8
• connective tissue growth factor
• CTGF
• HCS24
• Hypertrophic chondrocyte-specific protein 24
• IBP-8
• IGF-binding protein 8
• IGFBP8CCN family member 2
• Insulin-like growth factor-binding protein 8
• MGC102839
• NOV2

Background

CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF beta1, and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Recombinant human CTGF is a 11.2 kDa protein of 98 amino acid residues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Publications for CTGF/CCN2 Recombinant Protein (NBP1-91182)(1)

Publication using NBP1-91182

• Liu H, Yang R, Tinner B et al. Cysteine-rich protein 61 and connective tissue growth factor induce deadhesion and anoikis of retinal pericytes. Endocrinology. 2008-04-01 [PMID: 18187544]

FAQs for CTGF/CCN2 Recombinant Protein (NBP1-91182). (Showing 1 - 1 of 1 FAQ).

1. We are looking for a pair of mouse CTGF antibody for ELISA, we prefer no azide and/or glycerol, and in carrier free form (no EDTA, no Tris, no BSA). For the validation, we need approximately 100ug. If it works, we'll order more later.
   • Unfortunately we do not carry any CTGF antibodies that suit your specifications. We do carry AbSelect antibody purification kits that will remove BSA, Tris and azide from antibody formulations which may be an option for you.

Bioinformatics

• Gene Symbol: CCN2