CTGF/CCN2 Antibody (88430) - C-terminus

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CTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 25 µg/mL Human CTGF/CCN2 C-Terminus Monoclonal Antibody (Catalog # MAB660) overnight at 4 °C. ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
88430
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

CTGF/CCN2 Antibody (88430) - C-terminus Summary

Additional Information
C-terminal Peptide
Immunogen
E. coli-derived recombinant human CTGF
Glu247-Ala349
Accession # NP_001892.1
Specificity
Detects human CTGF C-teriminal peptide in direct ELISAs. Does not cross-react with recombinant human (rh) LDGF, rhNOV, rhPDGF, rhPlGF, rhVEGF206, rhVEGF-B186, rhVEGF-C, rhVEGF-D, or rhWISP-1.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CTGF
Purity
Protein A or G purified from ascites
Purity Statement
Protein A or G purified from ascites
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL
Control
CTGF/CCN2 Knockout HeLa Cell Lysate
Publications
Read Publications using
MAB660 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from ascites
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CTGF/CCN2 Antibody (88430) - C-terminus

  • CCN2
  • CCN2IGFBP-8
  • connective tissue growth factor
  • CTGF
  • CTGRP
  • Fisp12
  • HCS24
  • Hypertrophic chondrocyte-specific protein 24
  • IBP-8
  • IGF-binding protein 8
  • IGFBP-8
  • IGFBP8CCN family member 2
  • Insulin-like growth factor-binding protein 8
  • MGC102839
  • NOV2

Background

CTGF belongs to the CCN (CYR61/CTGF/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains IGF-binding protein domain, a von Willebrand factor type C domain, a thrombospondin type I domain, and a cysteine knot domain. The multimodular CTGF has the ability to bind multiple ligands and has numerous effects on development, differentation, and disease. The C-terminal cysteine knot motif contains the heparin and low density lipoprotein receptor (LDLR) binding sites that contributes to the adhesive and mitogenic properties of CTGF.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CTGF/CCN2 Antibody (MAB660)(6)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Bioassay, ELISA Development, IHC, Western Blot.


Filter By Application
Bioassay
(1)
ELISA Development
(1)
IHC
(2)
Western Blot
(2)
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Human
(5)
Mouse
(1)
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Showing Publications 1 - 6 of 6.
Publications using MAB660 Applications Species
JT Chen, CY Wang, MH Chen Curcumin inhibits TGF-?1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts J. Formos. Med. Assoc., 2018;0(0):. 2018 [PMID: 29339038] (IHC, Human) IHC Human
Yun Wang Human gingiva transcriptome during wound healing J. Clin. Periodontol, 2016;0(0):. 2016 [PMID: 28005267] (IHC, Human) IHC Human
Gao W, Cai L, Xu X, Fan J, Xue X, Yan X, Qu Q, Wang X, Zhang C, Wu G Anti-CTGF single-chain variable fragment dimers inhibit human airway smooth muscle (ASM) cell proliferation by down-regulating p-Akt and p-mTOR levels. PLoS ONE, 2014;9(12):e113980. 2014 [PMID: 25478966] (ELISA Development, Human) ELISA Development Human
Alfaro, Maria P, Deskins, Desirae, Wallus, Meredith, DasGupta, Jayasri, Davidson, Jeffrey, Nanney, Lillian, A Guney, Michelle, Gannon, Maureen, Young, Pampee P A physiological role for connective tissue growth factor in early wound healing. Lab Invest, 2013;93(1):81-95. 2013 [PMID: 23212098] (Bioassay, Mouse) Bioassay Mouse
Chen, Pai-Shen, Wang, Ming-Yan, Wu, Shin-Ni, Su, Jen-Lian, Hong, Chih-Che, Chuang, Shuang-E, Chen, Min-Wei, Hua, Kuo-Tai, Wu, Yu-Ling, Cha, Shih-Tin, Babu, Munisamy, Chen, Chiung-N, Lee, Po-Huang, Chang, King-Jen, Kuo, Min-Lian CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway. J Cell Sci, 2007;120(0):2053-65. 2007 [PMID: 17550972] (Western Blot, Human) Western Blot Human
Gronborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A, Pandey A Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol. Cell Proteomics, 2006;5(1):157-71. 2006 [PMID: 16215274] (Western Blot, Human) Western Blot Human

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FAQs for CTGF/CCN2 Antibody (MAB660). (Showing 1 - 1 of 1 FAQs).

  1. We are looking for a pair of mouse CTGF antibody for ELISA, we prefer no azide and/or glycerol, and in carrier free form (no EDTA, no Tris, no BSA). For the validation, we need approximately 100ug. If it works, we'll order more later.
    • Unfortunately we do not carry any CTGF antibodies that suit your specifications. We do carry AbSelect antibody purification kits that will remove BSA, Tris and azide from antibody formulations which may be an option for you.

Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol CTGF
Uniprot