CTGF/CCN2 Antibody (88430) - C-terminus

Images

 
CTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 25 µg/mL Human CTGF/CCN2 C-Terminus Monoclonal Antibody (Catalog # MAB660) overnight at 4 °C. Tissue was ...read more
Immunostaining of neuroendocrine tumors. Representative photomicrographs demonstrating anti-connective tissue growth factor (CCN2) (panel A) immunostaining of gut carcinoid tumor tissue. CCN2 immunoreactivity was seen ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
88430
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price

CTGF/CCN2 Antibody (88430) - C-terminus Summary

Additional Information
C-terminal Peptide
Immunogen
E. coli-derived recombinant human CTGF
Glu247-Ala349
Accession # NP_001892.1
Specificity
Detects human CTGF C-teriminal peptide in direct ELISAs. Does not cross-react with recombinant human (rh) LDGF, rhNOV, rhPDGF, rhPlGF, rhVEGF206, rhVEGF-B186, rhVEGF-C, rhVEGF-D, or rhWISP-1.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CTGF
Purity
Protein A or G purified from ascites
Purity Statement
Protein A or G purified from ascites
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL
Publications
Read Publications using
MAB660 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from ascites
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CTGF/CCN2 Antibody (88430) - C-terminus

  • CCN2
  • CCN2IGFBP-8
  • connective tissue growth factor
  • CTGF
  • CTGRP
  • Fisp12
  • HCS24
  • Hypertrophic chondrocyte-specific protein 24
  • IBP-8
  • IGF-binding protein 8
  • IGFBP-8
  • IGFBP8CCN family member 2
  • Insulin-like growth factor-binding protein 8
  • MGC102839
  • NOV2

Background

CTGF belongs to the CCN (CYR61/CTGF/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains IGF-binding protein domain, a von Willebrand factor type C domain, a thrombospondin type I domain, and a cysteine knot domain. The multimodular CTGF has the ability to bind multiple ligands and has numerous effects on development, differentation, and disease. The C-terminal cysteine knot motif contains the heparin and low density lipoprotein receptor (LDLR) binding sites that contributes to the adhesive and mitogenic properties of CTGF.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CTGF/CCN2 Antibody (MAB660)(10)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Bioassay, ELISA Development, IHC, Western Blot.


Filter By Application
Bioassay
(1)
ELISA Development
(1)
IHC
(2)
Western Blot
(2)
All Applications
Filter By Species
Human
(5)
Mouse
(1)
All Species
Showing Publications 1 - 10 of 10.
Publications using MAB660 Applications Species
JT Chen, CY Wang, MH Chen Curcumin inhibits TGF-?1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts J. Formos. Med. Assoc., 2018-01-17;0(0):. 2018-01-17 [PMID: 29339038] (IHC, Human) IHC Human
Yun Wang Human gingiva transcriptome during wound healing J. Clin. Periodontol, 2017-02-11;0(0):. 2017-02-11 [PMID: 28005267] (IHC, Human) IHC Human
Rodrigues-Pinto R, Berry A, Piper-Hanley K et al. Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord-specific markers during early human intervertebral disc development. J Orthop Res 8/1/2016 [PMID: 26910849]
Gao W, Cai L, Xu X, Fan J, Xue X, Yan X, Qu Q, Wang X, Zhang C, Wu G Anti-CTGF single-chain variable fragment dimers inhibit human airway smooth muscle (ASM) cell proliferation by down-regulating p-Akt and p-mTOR levels. PLoS ONE, 2014-12-05;9(12):e113980. 2014-12-05 [PMID: 25478966] (ELISA Development, Human) ELISA Development Human
B. ALDHOON, T. KUČERA, N. SMORODINOVÁ, J. MARTÍNEK, V. MELENOVSKÝ, J. KAUTZNER Associations Between Cardiac Fibrosis and Permanent Atrial Fibrillation in Advanced Heart Failure Physiological Research 2013-06-30 [PMID: 23489193]
Alfaro , Maria P, Deskins , Desirae, Wallus , Meredith, DasGupta , Jayasri, Davidson , Jeffrey, Nanney , Lillian, A Guney , Michelle, Gannon , Maureen, Young , Pampee P A physiological role for connective tissue growth factor in early wound healing. Lab Invest, 2012-11-19;93(1):81-95. 2012-11-19 [PMID: 23212098] (Bioassay, Mouse) Bioassay Mouse
Edward G. Tall, Audrey M. Bernstein, Noelynn Oliver, Julia L. Gray, Sandra K. Masur TGF-beta –Stimulated CTGF Production Enhanced by Collagen and Associated with Biogenesis of a Novel 31-kDa CTGF Form in Human Corneal Fibroblasts Investigative Opthalmology & Visual Science 2010-10-01 [PMID: 20393108]
Deidi Strickland Bergestuen, Jørgen Gravning, Kristina Hermann Haugaa, Laura G Sahakyan, Svend Aakhus, Espen Thiis-Evensen et al. Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors BMC Cancer 2010-12-01 [PMID: 20053285]
Chen , Pai-Shen, Wang , Ming-Yan, Wu , Shin-Ni, Su , Jen-Lian, Hong , Chih-Che, Chuang , Shuang-E, Chen , Min-Wei, Hua , Kuo-Tai, Wu , Yu-Ling, Cha , Shih-Tin, Babu , Munisamy, Chen , Chiung-N, Lee , Po-Huang, Chang , King-Jen, Kuo , Min-Lian CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway. J Cell Sci, 2007-06-15;120(0):2053-65. 2007-06-15 [PMID: 17550972] (Western Blot, Human) Western Blot Human
Gronborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A, Pandey A Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol. Cell Proteomics, 2005-10-08;5(1):157-71. 2005-10-08 [PMID: 16215274] (Western Blot, Human) Western Blot Human

Reviews for CTGF/CCN2 Antibody (MAB660) (0)

There are no reviews for CTGF/CCN2 Antibody (MAB660). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for CTGF/CCN2 Antibody (MAB660). (Showing 1 - 1 of 1 FAQs).

  1. We are looking for a pair of mouse CTGF antibody for ELISA, we prefer no azide and/or glycerol, and in carrier free form (no EDTA, no Tris, no BSA). For the validation, we need approximately 100ug. If it works, we'll order more later.
    • Unfortunately we do not carry any CTGF antibodies that suit your specifications. We do carry AbSelect antibody purification kits that will remove BSA, Tris and azide from antibody formulations which may be an option for you.
mFluor Violet Conjugated Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our CTGF/CCN2 Antibody (88430) - C-terminus and receive a gift card or discount.

Bioinformatics

Gene Symbol CTGF
Uniprot