Hu, Mu, RtApplications:
WB, ICC/IF, IHC, IHC-PHost:
Host: Sheep Polyclonal
WB, EIA, ELISA, PEP-ELISA, S-ELISAHost:
Applications: WB, IP
Applications: WB, ELISA, PA
Applications: B/N, Ctrl
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. The transcript variants are formed through the use of alternative translation initiation sites and promoters.
Research Areas for COMT
Find related products by research area and learn more about each of the different research areas below.Lipid and Metabolism
Bioinformatics Tool for COMT
Discover related pathways, diseases and genes to COMT. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.