Complement Factor B Antibody (313011)

• Reactivity: Hu
• Applications: WB, IP
• Clone: 313011
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

Complement Factor B Antibody (313011) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Complement Factor B
  Thr26-Leu764
  Accession # P00751
• Specificity: Detects human Complement Factor B in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) Factor D or rhFactor I.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: CFB
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Complement Factor B Antibody (313011)

• BF AHUS4
• BF
• B-factor, properdin
• BFD
• C3 proaccelerator
• C3 proactivator
• C3/C5 convertase
• CFAB
• CFB
• Complement Factor B
• EC 3.4.21
• EC 3.4.21.47
• FB
• FBI12
• GBG
• GBGCFAB
• Glycine-rich beta glycoprotein
• glycine-rich beta-glycoprotein
• H2-Bf
• PBF2
• Properdin factor B

Background

Complement Factor B, also known as C3/C5 convertase, is a serine protease of the alternative pathway of the complement system. The amino acid sequence of human Complement Factor B is 85% identical to that of rat and mouse.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Complement Factor B Antibody (MAB2739)(1)

Publication using MAB2739

• SJ Clark, S McHarg, V Tilakaratn, N Brace, PN Bishop Bruch's Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration Front Immunol, 2017-12-19;8(0):1778. 2017-12-19 [PMID: 29312308]

Bioinformatics

• Gene Symbol: CFB
• Uniprot:
  • P00751()