Complement C3 Antibody (755)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IA
Clone
755
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

Complement C3 Antibody (755) Summary

Immunogen
Human C3/C3b
Specificity
This reacts with an epitope on C3b and recognizes cleaved C3b and full C3 which plays a central role in the complement system. Does not cross-react with C3a.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
C3
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:50
  • Immunoassay
Application Notes
In WB: The band size (s) are ~190 and ~100 kDa under non-reducing and reducing conditions, respectively.

Reactivity Notes

Cross-reacts with Human. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, containing 0.1% BSA
Preservative
0.02% Sodium Azide
Concentration
0.1 mg/ml
Purity
Protein A or G purified

Alternate Names for Complement C3 Antibody (755)

  • AHUS5
  • ARMD9
  • ASP
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
  • complement C3
  • complement component 3
  • complement component C3
  • CPAMD1acylation-stimulating protein cleavage product

Background

The complement system is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead to the cleavage of the third complement component C3. C3 is cleaved into C3a and C3b, where C3b becomes attached to immune complexes. Futhermore C3b plays a critical role in the amplification loop of the alternative pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Complement C3 Antibody (NB200-617). (Showing 1 - 2 of 2 FAQ).

  1. I am trying to establish a method to measure mice C3 levels by nephelometry. I would be most grateful if you could provide me with some help, regarding the choice of the Ab. I totally understand that since such a method has never been tried, I do not expect any guaranties. 
    • We have never performed nephelometry in our lab, and do not have a protocol or advice to provide about this application. However, it seems to me that you should choose an antibody that is capable of recognizing its target in its folded conformation. Therefore, I would suggest trying an antibody that has been validated for ICC or IHC.
  2. What is the protocol for IHC staining using complement c3?
    • We don't appear to have a specific protocol for this product, however we do have a general protocol under the support area of our website that may be of assistance. I would recommend a starting dilution of 1:100 for IHC which you will then need to optimize.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Complement C3 Antibody (NB200-617)

Discover related pathways, diseases and genes to Complement C3 Antibody (NB200-617). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for Complement C3 Antibody (NB200-617)

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Blogs on Complement C3.

Complement C3 - the most important protein in the complement system
The complement system is made up of a collection of proteins found in the bloodstream and is comprised of nine major complement proteins; complement C3 is one of them. The complement system is a crucial component of the cellular immune system becau...  Read full blog post.

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Bioinformatics

Gene Symbol C3
Entrez
Uniprot