Complement C3 Products

Antibodies
Complement C3 Antibody
Complement C3 Antibody
Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF, IHC-P, IP
Host: Rabbit Polyclonal
ELISA Kits
Complement C3 ELISA Kit [Biot ...
Complement C3 ELISA Kit [Biotin]
KA0466
Species: Hu
Complement C3 ELISA Kit [HRP] ...
Complement C3 ELISA Kit [HRP]
KA1926
Species: Mu
Complement C3 ELISA Kit [HRP] ...
Complement C3 ELISA Kit [HRP]
KA1923
Species: Ca
Proteins
Complement C3 Recombinant Pro ...
Complement C3 Recombinant Protein
P3343
Species: Mu
Applications: WB, ELISA, PA
Complement C3 Partial Recombi ...
Complement C3 Partial Recombinant ...
H00000718-Q01
Species: Hu
Applications: WB, ELISA, PA
Complement C3 Recombinant Pro ...
Complement C3 Recombinant Protein ...
NBP1-85493PEP
Species: Hu
Applications: AC
RNAi
Complement C3 RNAi
Complement C3 RNAi
H00000718-R01
Species: Hu

Description

In eukaryotic cells, DNA is associated with histones and other proteins to form chromatin. The cell division cycle constitutes a series of processes that have evolved to create two genetically identical daughter cells from a mother cell. One of these processes is the conversion of relatively amorphous, extended interphase chromatin into condensed, highly ordered mitotic chromosomes. Proper mitotic chromosome condensation is essential for the correct segregation of sister chromatids into two daughter cells. The basic unit of chromatin is the nucleosome core particle, which consists of 140 bp DNA wrapped around an octameric core containing two each of the four conserved core histones: H2A, H2B, H3 and H4. A fifth histone, the linker histone H1, interacts with DNA of variable length, linking adjacent nucleosome cores, and further compacting the chromatin. Chromatin changes are initiated during G2 phase of the cell cycle, in preparation for cell division. The most striking morphological change is chromatin condensation, which becomes apparent during prophase and is maximal during the subsequent stages of mitosis. Histone H1 and the N-terminal tail of H3 have key roles in the folding and inter-association of the chromatin fiber. Two currently known phosphorylation sites are present in the N-terminus of H3; serine-10 and serine-28.1,2 Mitogenic stimulation, oncogenic transformation, or induction of oncogenic ras expression are accompanied with increase in serine-10 phosphorylation of the H3 N-terminal domain. Indeed, it has been shown that phosphorylated H3 is associated with c-fos and c-myc genes in stimulated cells. Phosphorylation of H3, at both serine-10 and -28, coincides with the induction of mitotic chromosome condensation. H3 phosphorylation may contribute to proto-oncogene induction by modulating chromatin structure and releasing blocks in elongation. In contrast to H1 hyperphosphorylation, site-specific phosphorylation of core histone H3 at serine-10 and -28 appears to occur exclusively during mitosis in mammalian cells. H3 dephosphorylation occurs quite rapidly after mitosis and serine-10/28 remain unphosphorylated throughout the remainder of interphase. PP1 has been identified as the H3 phosphatase. Monoclonal antibodies reacting specifically with phosphorylated histone H3, are useful tools to study molecular mechanisms associated with the G2 to M transition and chromatin condensation, and for the analysis of protein kinase(s) and phosphatase(s) involved in H3 phosphorylation or dephosphorylation. They may also be used in multiparameter analysis to relate H3 phosphorylation in ndividual cells to the cell

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Mouse
Rat
Product By Gene ID 718
Alternate Names
  • ARMD9
  • complement component C3
  • AHUS5
  • complement C3
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
  • CPAMD1acylation-stimulating protein cleavage product
  • ASP
  • complement component 3

Research Areas for Complement C3

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Neuronal Cell Markers
Neuroscience

Bioinformatics Tool for Complement C3

Discover related pathways, diseases and genes to Complement C3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Complement C3 Blog Posts

Check out the latest blog posts on Complement C3.
Complement C3 - the most important protein in the complement system
The complement system is made up of a collection of proteins found in the bloodstream and is comprised of nine major complement proteins; complement C3 is one of them. The complement system is a crucial component of the cellular immune system becau...    Read more.
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