ELISA: Use at an assay dependent dilution. ICC: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Western Blot: Use at a concentration of 0.4 ug/ml. Detects a band of approximately 55 kDa. Optimal dilutions/concentrations should be determined by the end user.
Cross-reacts with Human.Not yet tested in other species.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
10mM PBS (pH 7.4)
15mM Sodium Azide
Protein A or G purified
Alternate Names for CDC7 Antibody (DCS-341)
CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
CDC7 cell division cycle 7 (S. cerevisiae)
cell division cycle 7 (S. cerevisiae)
cell division cycle 7 homolog (S. cerevisiae)
cell division cycle 7-like protein 1
cell division cycle 7-related protein kinase
DNA replication in eukaryotic cells is dependent on the phosphorylation of the pre-replicative complex (preRC) at the origin of replication. Two complexes of proteins mediate this event, the cyclin dependent kinase (CDK) complex, and the Cdc7 kinase-ASK complex. Human Cdc7 kinase consists of 574 amino acids with a molecular weight of 55 kDa. The activity of Cdc7 kinase oscillates during cell cycle. The major targets of Cdc7 kinase are proteins that belong to the MCM complex (mini chromosome maintenance proteins). Cdc7 kinase was also found to be important in meiosis, checkpoint responses, maintenance of chromosome structure, and repair.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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