Cdc14B Antibody - BSA Free

Immunohistochemistry-Paraffin: Cdc14B Antibody [NBP1-84572] - Staining of human cerebellum shows strong nuclear membranous positivity in Purkinje cells.

• Reactivity: Hu, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Cdc14B Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: VENQDQQEPEPYSDDDEINGVTQGDRSRAL
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CDC14B
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  Cdc14B Protein (NBP1-84572PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (80%), Rat (83%). Monkey reactivity reported in scientific literature (PMID: 29293958).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Cdc14B Antibody - BSA Free

• CDC14 cell division cycle 14 homolog B (S. cerevisiae)
• CDC14 cell division cycle 14 homolog B
• S. cerevisiae) homolog B

Background

Cdc14B is encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Cdc14B Antibody (NBP1-84572)(1)

Publication using NBP1-84572

• Imtiaz A, Belyantseva IA, Beirl AJ et al. CDC14A Phosphatase is Essential for Hearing and Male Fertility in Mouse and Human. Hum. Mol. Genet. 2017-12-23 [PMID: 29293958] (Monkey)

Bioinformatics

• Gene Symbol: CDC14B