CD94 Antibody (DX22) - BSA Free

Flow Cytometry: CD94 Antibody (DX22) [NB100-64104] - Analysis using the FITC conjugate of NB100-64104. Staining of human peripheral blood lymphocytes.

Flow Cytometry: CD94 Antibody (DX22) [NB100-64104] - Staining of human peripheral blood lymphocytes.

Flow Cytometry: CD94 Antibody (DX22) [NB100-64104] - Staining of human peripheral blood lymphocytes using CD94 PE.

Flow Cytometry: CD94 Antibody (DX22) [NB100-64104] - Analysis using the Biotin conjugate of NB100-64104. Staining of human peripheral blood lymphocytes.

• Reactivity: Hu
• Applications: Flow
• Clone: DX22
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

CD94 Antibody (DX22) - BSA Free Summary

• Description: Novus Biologicals Mouse CD94 Antibody (DX22) - BSA Free (NB100-64104) is a monoclonal antibody validated for use in Flow. Anti-CD94 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Natural killer cell line
• Specificity: NB100-64104 is specific for human CD94, also known as KLRD1 (Killer cell lectin-like receptor, subfamily D, member 1). CD94 is expressed on natural killer (NK) cells and a subset of T lymphocytes. CD94 is found to associate with NKG2 to form a heterodimer which is involved in the inhibition of cell mediated cytotoxicity against cells bearing appropriate MHC class I allotypes. Clone DX22 is reported to inhibit the binding of CD94 to HLA-E(2) and HLA-G(4).
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: KLRD1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:50-1:100
• Control:

  CD94 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A purified

Alternate Names for CD94 Antibody (DX22) - BSA Free

• CD94 antigen
• CD94
• CD94natural killer cells antigen CD94
• Killer cell lectin-like receptor subfamily D member 1
• killer cell lectin-like receptor subfamily D, member 1
• KLRD1
• KP43
• NK cell receptor

Background

CD94 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T cells. Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CD94 Antibody (NB100-64104)(1)

Publication using NB100-64104

• KrAmer B, Nalin A, Ma F et al. Single-cell RNA sequencing identifies a population of human liver-type ILC1s Cell Reports 2023-01-01 [PMID: 36640314]

Bioinformatics

• Gene Symbol: KLRD1
• Uniprot:
  • Q13241()