NKG2A/CD159a/KLRC1 Antibody (131411) [Unconjugated]

Images

 
Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2A/CD159a Monoclonal ...read more
HEK293 Human embryonic kidney cell line transfected with either (A) Human NKG2A/CD159a, or (B) Human NKG2B/CD159b and eGFP was stained with Mouse Anti-Human NKG2A/CD159a Monoclonal Antibody (Catalog # MAB1059) followed ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
131411
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

NKG2A/CD159a/KLRC1 Antibody (131411) [Unconjugated] Summary

Immunogen
BaF3 mouse pro-B cell line transfected with human NKG2A and CD94
Specificity
Recognizes the human NKG2A/CD94 heterodimer. It does not recognize the NKG2C/CD94 heterodimer or the CD94 homodimer.
Details of Functionality
ActivityAssaywCitation not found None
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
KLRC1
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25 ug/10^6 cells
  • CyTOF-ready
Publications
Read Publications using
MAB1059 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NKG2A/CD159a/KLRC1 Antibody (131411) [Unconjugated]

  • CD159 antigen-like family member A
  • CD159a antigen
  • CD159a
  • C-lectin type II protein
  • killer cell lectin-like receptor subfamily C, member 1
  • Klrc1
  • MGC13374
  • natural killer cell lectin
  • natural killer group protein 2
  • NK cell receptor A
  • NKG2
  • NKG2-1/B activating NK receptor
  • NKG2A
  • NKG2-A
  • NKG2-A/B type II integral membrane protein
  • NKG2-A/B-activating NK receptor
  • NKG2-A/NKG2-B type II integral membrane protein
  • NKG2AMGC59791
  • NKG2-B

Background

NKG2A, also known as CD159a, is a type II transmembrane receptor having a single extracellular lectin-like domain and a cytoplasmic ITIM motif. It associates with CD94 and is expressed on NK cells and some activated T cell populations. The NKG2A/CD94 complex delivers an inhibitory signal upon recognition of its ligand, HLA-E.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for NKG2A/CD159a/KLRC1 Antibody (MAB1059)(12)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Flow Cytometry, Functional Assay, Immunoprecipitation, Neutralization.


Filter By Application
Flow Cytometry
(8)
Functional Assay
(1)
Immunoprecipitation
(1)
Neutralization
(2)
All Applications
Filter By Species
Human
(11)
Mouse
(1)
All Species
Showing Publications 1 - 10 of 12. Show All 12 Publications.
Publications using MAB1059 Applications Species
WC Pump, T Kraemer, T Huyton, GT Hò, R Blasczyk, C Bade-Doedi Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8? T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia Int J Mol Sci, 2019;20(6):. 2019 [PMID: 30909402] (Immunoprecipitation, Human) Immunoprecipitation Human
B Müller-Dur, J Grählert, OP Devine, AN Akbar, C Hess CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age Aging (Albany NY), 2019;11(2):724-740. 2019 [PMID: 30686790] (Flow Cytometry, Human) Flow Cytometry Human
H Sun, J Xu, Q Huang, M Huang, K Li, K Qu, H Wen, R Lin, M Zheng, H Wei, W Xiao, R Sun, Z Tian, C Sun Reduced CD160 expression contributes to impaired NK cell function and poor clinical outcomes in patients with HCC Cancer Res., 2018;0(0):. 2018 [PMID: 30232222] (Flow Cytometry, Human) Flow Cytometry Human
Y Xia, Q Zhang, Q Zhen, Y Zhao, N Liu, T Li, Y Hao, Y Zhang, C Luo, X Wu Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway Oncotarget, 2017;8(23):37783-37795. 2017 [PMID: 28384121] (Flow Cytometry, Human) Flow Cytometry Human
Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, Zheng Q, Ran Z WNT5A transforms intestinal CD8alphaalpha(+) IELs into an unconventional phenotype with pro-inflammatory features. BMC Gastroenterol, 2015;15(0):173. 2015 [PMID: 26652024] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Wang F, Zhou Y, Fu B, Wu Y, Zhang R, Sun R, Tian Z, Wei H Molecular signatures and transcriptional regulatory networks of human immature decidual NK and mature peripheral NK cells. Eur J Immunol, 2014;44(9):2771-84. 2014 [PMID: 24838931] (Flow Cytometry, Human) Flow Cytometry Human
Serrano-Pertierra E, Cernuda-Morollon E, Brdicka T, Hooejsi V, Lopez-Larrea C L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration. J Leukoc Biol, 2014;96(3):437-45. 2014 [PMID: 24803550] (Neutralization, Human) Neutralization Human
Nachmani D, Zimmermann A, Oiknine Djian E, Weisblum Y, Livneh Y, Khanh Le V, Galun E, Horejsi V, Isakov O, Shomron N, Wolf D, Hengel H, Mandelboim O MicroRNA editing facilitates immune elimination of HCMV infected cells. PLoS Pathog, 2014;10(2):e1003963. 2014 [PMID: 24586166] (Flow Cytometry, Human) Flow Cytometry Human
Angelini DF, Zambello R, Galandrini R, Diamantini A, Placido R, Micucci F, Poccia F, Semenzato G, Borsellino G, Santoni A, Battistini L NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease. J. Leukoc. Biol., 2011;89(1):75-84. 2011 [PMID: 20952657] (Flow Cytometry, Human) Flow Cytometry Human
Dulphy N, Haas P, Busson M, Belhadj S, Peffault de Latour R, Robin M, Carmagnat M, Loiseau P, Tamouza R, Scieux C, Rabian C, Di Santo JP, Charron D, Janin A, Socie G, Toubert A An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation. J. Immunol., 2008;181(3):2227-37. 2008 [PMID: 18641363] (Functional Assay, Human) Functional Assay Human
Show All 12 Publications.

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Bioinformatics

Gene Symbol KLRC1