NKG2C/CD159c/KLRC2 Antibody (134591) [Unconjugated]


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Product Details

Reactivity HuSpecies Glossary
Applications Flow, CyTOF-reported

Order Details

NKG2C/CD159c/KLRC2 Antibody (134591) [Unconjugated] Summary

BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
Detects human NKG2C/CD159c heterodimer with CD94 in flow cytometry. It does not cross-react with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer.
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • CyTOF-reported
  • Flow Cytometry 2.5 ug/10^6 cells
Read Publications using
MAB138 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NKG2C/CD159c/KLRC2 Antibody (134591) [Unconjugated]

  • CD159 antigen-like family member C
  • CD159c antigen
  • CD159c
  • killer cell lectin-like receptor subfamily C, member 2
  • KLRC2
  • MGC138244
  • NK cell receptor C
  • NKG2-C type II integral membrane protein
  • NKG2C
  • NKG2-C
  • NKG2CNKG2-C-activating NK receptor


Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins. Natural killer (NK) receptors are expressed in both NK cells and cytotoxic CD8+ T cells and have both activating and inhibitory members (1-3). Regulation of the balance between the activating and inhibitory receptors is important and lack of such regulation has been implicated in autoimmunity (4). The NKG2 family includes seven receptors: NKG2A, -B, -C, -D, -E, -F, and -H, which is the longer isoform of NKG2E. Except for NKG2D and NKG2F, the NKG2 family members form heterodimers with CD94 (5, 6). NKG2C interacts with the adapter molecule DAP12 and acts as activating receptor when heterodimerized with CD94 (7). Human NKG2C is synthesized as a 231 amino acid (aa) protein that includes a 70 aa cytoplasmic domain, a 23 aa transmembrane segment, and a 138 aa extracellular domain (ECD). Within the ECD, human NKG2C shares 40% sequence identity with mouse NKG2C. NKG2C-CD94 heterodimers bind to the widely expressed nonclassical MHC-I molecule, HLA-E (Qa-1b in mouse), which presents a peptide derived from the signal peptide of classical MHC-I molecules (8, 9). Triggering the NKG2C-CD94 complex may activate the cytolytic activity and cytokine production of NK and CD8+ T cells (8, 10). Human cytomegalovirus (HCMV) infection promotes the differentiation and expansion of NKG2C+ NK cell subsets, possibly involving a cognate interaction of CD94/NKG2C with ligand(s) displayed by HCMV‑infected cells (11, 12).
  1. Orbelyan, G.A. et al. (2014) J. Immunol. 193:610.
  2. Tassi I. et al. (2006) Immnunol Rev. 214:92.
  3. Lanier, L.L. (2008) Nat. Immunol. 9:495.
  4. Schleinitz, N. et al. (2010) Immunology. 174:2878.
  5. Lopez-Botet, M. et al. (2000) Hum. Immunol. 61:7.
  6. Braud, V.M. et al. (1998) Nature. 391:795.
  7. Lanier, L.L. (1998) Immunity 8:693.
  8. Vance, R.E. et al. (1999) J Exp Med 190:1801.
  9. Kaiser B.K. et al. (2005) J Immunol 174:2878.
  10. Bellón T. et al. (1999) J Immunol 162:3996.
  11. Pupuleku A. et al. (2017) Front Immunol. 8:1317.
  12. Hammer Q. et al. (2018) Nat Immunol. 19:453.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for NKG2C/CD159c/KLRC2 Antibody (MAB138)(20)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

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Showing Publications 1 - 10 of 20. Show All 20 Publications.
Publications using MAB138 Applications Species
HR Wagstaffe, O Anzala, H Kibuuka, Z Anywaine, SB Sirima, R Thiébaut, L Richert, Y Levy, C Lacabaratz, V Bockstal, K Luhn, M Douoguih, MR Goodier NK Cell Subset Redistribution and Antibody Dependent Activation after Ebola Vaccination in Africans Vaccines, 2022;10(6):. 2022 [PMID: 35746491] (Flow Cytometry, Human) Flow Cytometry Human
L Jiang, H Fei, X Jin, X Liu, C Yang, C Li, J Chen, A Yang, J Zhu, H Wang, X Fei, S Zhang Extracellular Vesicle-Mediated Secretion of HLA-E by Trophoblasts Maintains Pregnancy by Regulating the Metabolism of Decidual NK Cells International journal of biological sciences, 2021;17(15):4377-4395. 2021 [PMID: 34803505] (Flow Cytometry, Human) Flow Cytometry Human
GM Wiedemann, EK Santosa, S Grassmann, S Sheppard, JB Le Luduec, NM Adams, C Dang, KC Hsu, JC Sun, CM Lau Deconvoluting global cytokine signaling networks in natural killer cells Nature Immunology, 2021;0(0):. 2021 [PMID: 33859404] (Flow Cytometry, Human) Flow Cytometry Human
D Brownlie, M Scharenber, JE Mold, J Hård, E Kekäläinen, M Buggert, S Nguyen, JN Wilson, M Al-Ameri, HG Ljunggren, N Marquardt, J Michaëlsso Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood Proceedings of the National Academy of Sciences of the United States of America, 2021;118(11):. 2021 [PMID: 33836578] (Flow Cytometry, Human) Flow Cytometry Human
DR Makanga, T Guillaume, C Willem, N Legrand, K Gagne, A Cesbron, K Gendzekhad, P Peterlin, A Garnier, A Le Bourgeo, MC Béné, P Chevallier, C Retière Posttransplant Cyclophosphamide and Antithymocyte Globulin versus Posttransplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis for Peripheral Blood Stem Cell Haploidentical Transplants: Comparison of T Cell and NK Effector Reconstitution J. Immunol., 2020;0(0):. 2020 [PMID: 32747504] (Flow Cytometry, Human) Flow Cytometry Human
EM Comeau, KA Holder, NJ Fudge, MD Grant Cytomegalovirus-Driven Adaption of Natural Killer Cells in NKG2Cnull Human Immunodeficiency Virus-Infected Individuals Viruses, 2019;11(3):. 2019 [PMID: 30857329] (Flow Cytometry, Human) Flow Cytometry Human
B Müller-Dur, J Grählert, OP Devine, AN Akbar, C Hess CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age Aging (Albany NY), 2019;11(2):724-740. 2019 [PMID: 30686790] (Flow Cytometry, Human) Flow Cytometry Human
G Martrus, T Kautz, S Lunemann, L Richert, L Glau, W Salzberger, H Goebels, A Langenecke, L Hess, T Poch, C Schramm, KJ Oldhafer, M Koch, E Tolosa, B Nashan, M Altfeld Proliferative capacity exhibited by human liver-resident CD49a+CD25+ NK cells PLoS ONE, 2017;12(8):e0182532. 2017 [PMID: 28792982] (Flow Cytometry, Human) Flow Cytometry Human
Raphaëlle Riou Severe symptomatic primary HCMV infection despite effective innate and adaptive immune responses J. Virol, 2016;0(0):. 2016 [PMID: 28031361] (Flow Cytometry, Human) Flow Cytometry Human
Huijskens M, Walczak M, Sarkar S, Atrafi F, Senden-Gijsbers B, Tilanus M, Bos G, Wieten L, Germeraad W Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy. Cytotherapy, 0;17(5):613-20. 0 [PMID: 25747742] (Flow Cytometry, Human) Flow Cytometry Human
Show All 20 Publications.

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Gene Symbol KLRC2