NKG2C/CD159c/KLRC2 Antibody (134591) [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-reported
Clone
134591
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

NKG2C/CD159c/KLRC2 Antibody (134591) [Unconjugated] Summary

Immunogen
BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
Specificity
Detects human NKG2C/CD159c heterodimer with CD94 in flow cytometry. It does not cross-react with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer.
Details of Functionality
ActivityAssaywCitation not found None
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KLRC2
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 2.5 ug/10^6 cells
  • CyTOF-reported
Publications
Read Publications using
MAB138 in the following applications:

  • 13 publications

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NKG2C/CD159c/KLRC2 Antibody (134591) [Unconjugated]

  • CD159 antigen-like family member C
  • CD159c antigen
  • CD159c
  • killer cell lectin-like receptor subfamily C, member 2
  • KLRC2
  • MGC138244
  • NK cell receptor C
  • NKG2-C type II integral membrane protein
  • NKG2C
  • NKG2-C
  • NKG2CNKG2-C-activating NK receptor

Background

NKG2C, also known as hemoglobin scavenger receptor, is a type II transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for NKG2C/CD159c/KLRC2 Antibody (MAB138)(13)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow.


Filter By Application
Flow
(13)
All Applications
Filter By Species
Human
(13)
All Species
Showing Publications 1 - 10 of 13. Show All 13 Publications.
Publications using MAB138 Applications Species
G Martrus, T Kautz, S Lunemann, L Richert, L Glau, W Salzberger, H Goebels, A Langenecke, L Hess, T Poch, C Schramm, KJ Oldhafer, M Koch, E Tolosa, B Nashan, M Altfeld Proliferative capacity exhibited by human liver-resident CD49a+CD25+ NK cells PLoS ONE, 2017;12(8):e0182532. 2017 [PMID: 28792982] (Flow,, Human) Flow Human
Raphaëlle Riou Severe symptomatic primary HCMV infection despite effective innate and adaptive immune responses J. Virol, 2016;0(0):. 2016 [PMID: 28031361] (Flow,, Human) Flow Human
Huijskens M, Walczak M, Sarkar S, Atrafi F, Senden-Gijsbers B, Tilanus M, Bos G, Wieten L, Germeraad W Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy. Cytotherapy, 0;17(5):613-20. 0 [PMID: 25747742] (Flow,, Human) Flow Human
Marquardt N, Beziat V, Nystrom S, Hengst J, Ivarsson M, Kekalainen E, Johansson H, Mjosberg J, Westgren M, Lankisch T, Wedemeyer H, Ellis E, Ljunggren H, Michaelsson J, Bjorkstrom N Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol, 2015;194(6):2467-71. 2015 [PMID: 25672754] (Flow,, Human) Flow Human
Nachmani D, Zimmermann A, Oiknine Djian E, Weisblum Y, Livneh Y, Khanh Le V, Galun E, Horejsi V, Isakov O, Shomron N, Wolf D, Hengel H, Mandelboim O MicroRNA editing facilitates immune elimination of HCMV infected cells. PLoS Pathog, 2014;10(2):e1003963. 2014 [PMID: 24586166] (Flow,, Human) Flow Human
Saghafian-Hedengren S, Sohlberg E, Theorell J, Carvalho-Queiroz C, Nagy N, Persson J, Nilsson C, Bryceson Y, Sverremark-Ekstrom E Epstein-Barr virus coinfection in children boosts cytomegalovirus-induced differentiation of natural killer cells. J Virol, 2013;87(24):13446-55. 2013 [PMID: 24089567] (Flow,, Human) Flow Human
Charoudeh H, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection. Eur J Immunol, 2013;43(2):480-7. 2013 [PMID: 23161492] (Flow,, Human) Flow Human
Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. PLoS Pathog., 2012;8(1):e1002486. 2012 [PMID: 22253598] (Flow,, Human) Flow Human
Angelini DF, Zambello R, Galandrini R, Diamantini A, Placido R, Micucci F, Poccia F, Semenzato G, Borsellino G, Santoni A, Battistini L NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease. J. Leukoc. Biol., 2011;89(1):75-84. 2011 [PMID: 20952657] (Flow,, Human) Flow Human
Yu J, Mao HC, Wei M, Hughes T, Zhang J, Park IK, Liu S, McClory S, Marcucci G, Trotta R, Caligiuri MA CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets. Blood, 2010;115(2):274-81. 2010 [PMID: 19897577] (Flow,, Human) Flow Human
Show All 13 Publications.

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Bioinformatics

Gene Symbol KLRC2
Entrez