CD41/CD61 Antibody (PAC-1)

Images

 
Flow Cytometry: CD41/CD61 Antibody (PAC-1) [NBP2-62201] - Separation of CD41/CD61 positive platelets (red-filled) from CD41/CD61 negative nucleated cells (black-dashed) in flow cytometry analysis (surface staining) of ...read more
Flow (Cell Surface): CD41/CD61 Antibody (PAC-1) [NBP2-62201] - Surface staining of PAC-1 on PHA-activated (1 hour) human peripheral blood with anti-PAC-1 (PAC-1) FITC.
Flow (Cell Surface): CD41/CD61 Antibody (PAC-1) [NBP2-62201] - Surface staining pattern of PHA stimulated human peripheral whole blood stained using anti-human CD41/CD61 (PAC-1) purified antibody (concentration in ...read more
Flow Cytometry: CD41/CD61 Antibody (PAC-1) [NBP2-62201] - Multicolor staining pattern of human lymphocytes stained using anti-human CD41/CD61 (PAC-1) purified antibody (concentration in sample 8 ug/ml, GAM PE) and ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, Flow-CS, IP, ICC/IF
Clone
PAC-1
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

CD41/CD61 Antibody (PAC-1) Summary

Immunogen
Human platelets
Specificity
The antibody MEM-G/9 reacts with native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. Reactivity with HLA-G3 was also reported. The antibody MEM-G/9 is standard reagent thoroughly validated during 3rd International Conference on HLA-G (Paris, 2003).
Isotype
IgM Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ITGA2B
Purity
Multi-step
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow (Cell Surface)
  • Flow Cytometry 2-4 ug/ml
  • Immunocytochemistry
  • Immunoprecipitation 1:10-1:500
Application Notes
Purified from cell culture supernatant by PEG precipitation and hydroxyapatite chromatography.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS (pH 8.0)
Preservative
15mM Sodium Azide
Purity
Multi-step

Alternate Names for CD41/CD61 Antibody (PAC-1)

  • CD41 antigen
  • CD41
  • CD41BHPA3
  • GP2Bintegrin alpha-IIb
  • GPalpha IIb
  • GPIIb
  • GTA
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41)
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B)
  • ITGAB
  • platelet fibrinogen receptor, alpha subunit
  • Platelet membrane glycoprotein IIb
  • platelet-specific antigen BAK

Background

Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ITGA2B