CD41/CD61 Products

Description

Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.

Bioinformatics

Product By Gene ID	3674
Alternate Names	CD41 antigen CD41 CD41BHPA3 GP2Bintegrin alpha-IIb GPalpha IIb GPIIb GTA integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41) integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B) ITGAB platelet fibrinogen receptor, alpha subunit Platelet membrane glycoprotein IIb platelet-specific antigen BAK

Diseases related to CD41/CD61

Discover more about diseases related to CD41/CD61.

Thrombasthenia
Hemorrhage
Tissue Adhesions
Von Willebrand Disease
Thrombosis
Bleeding Tendency
Thrombus
Myocardial Infarction
Infarction
5,10-methylenetetrahydrofolate Reductase Deficiency
Hereditary Diseases
Inflammation
Cerebrovascular Accident
Disease Of Adrenal Medulla
Immunologic Deficiency Syndromes
Angina, Unstable
Hemorrhagic Disorders
Bernard-soulier Syndrome
Cardiovascular Diseases

Pathways for CD41/CD61

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Platelet Aggregation
Platelet Activation
Hemostasis
Secretion
Pathogenesis
Mrna Splicing
Reverse Transcription
Localization
Coagulation
Protein Phosphorylation
Transport
Clathrin-mediated Endocytosis
Developmental Process
Immune Response
Inner Ear Development
Embryo Development
Blastocyst Formation
Membrane Depolarization
Cell Cycle
Cyclooxygenase Pathway

Research Areas for CD41/CD61

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
Cellular Markers
Cytoskeleton Markers
Extracellular Matrix
Immunology
Signal Transduction
Stem Cell Markers

PTMs for CD41/CD61

Learn more about PTMs related to CD41/CD61.

Phosphorylation
Sulphation
Glycosylation
Acetylation
Dephosphorylation
Deglycosylation

Bioinformatics Tool for CD41/CD61

Discover related pathways, diseases and genes to CD41/CD61. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.