CD11c Antibody (3.9)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF, IHC, IP, CyTOF-ready
Clone
3.9
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

CD11c Antibody (3.9) Summary

Immunogen
Rheumatoid synovial fluid cells and fibronectin purified human monocytes
Localization
Type I membrane protein.
Marker
Dendritic Cell Marker
Specificity
CD11c; gp150/95 a subunit
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGAX
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1 ug per 1x10^6
  • Immunocytochemistry/Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • CyTOF-ready
Application Notes
Shown to inhibit adhesion (PMID: 22844116). This antibody is CyTOF ready.
Theoretical MW
150 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Protein A purified

Notes

Positive control(s): Peripheral blood monocytes (PBMCs) (FACS), Uterine tissue sections (IHC).

Alternate Names for CD11c Antibody (3.9)

  • 95 alpha chain
  • 95
  • 95, alpha subunit
  • CD11 antigen-like family member C
  • CD11c antigen
  • CD11c
  • CD11Cleu M5, alpha subunit
  • Integrin alpha X
  • integrin alpha-X
  • integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
  • integrin, alpha X (complement component 3 receptor 4 subunit)
  • ITGAX
  • Leu M5
  • Leukocyte adhesion glycoprotein p150
  • Leukocyte adhesion receptor p150
  • leukocyte surface antigen p150
  • myeloid membrane antigen, alpha subunit
  • p150 95 integrin alpha chain
  • p150,95 alpha
  • SLEB6

Background

CD11c (integrin alpha X chain protein) combines with the beta 2 chain (ITGB2) to form a leukocyte specific integrin referred to as inactivated C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. The CD11c antigen is a marker for hairy cell leukaemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for CD11c Antibody (NB100-2711) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB100-2711AF350
Alexa Fluor 405 NB100-2711AF405
Alexa Fluor 488 NB100-2711AF488
Alexa Fluor 532 NB100-2711AF532
Alexa Fluor 594 NB100-2711AF594
Alexa Fluor 647 NB100-2711AF647
Alexa Fluor 700 NB100-2711AF700
Alexa Fluor 750 NB100-2711AF750
Allophycocyanin/Cy7 NB100-2711APCCY7
DyLight 350 NB100-2711UV
DyLight 405 NB100-2711V
DyLight 488 NB100-2711G
DyLight 550 NB100-2711R
DyLight 594 NB100-2711DL594
DyLight 650 NB100-2711C
DyLight 680 NB100-2711FR
DyLight 755 NB100-2711IR
HRP NB100-2711H
Janelia Fluor 549 NB100-2711JF549
Janelia Fluor 646 NB100-2711JF646
PE NB100-2711PE
PE/Atto594 NB100-2711PEATT594
PE/Cy5.5 NB100-2711PECY55
PE/Cy7 NB100-2711PECY7
PerCP NB100-2711PCP

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Bioinformatics Tool for CD11c Antibody (NB100-2711)

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Research Areas for CD11c Antibody (NB100-2711)

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Blogs on CD11c.

Gut-brain axis: microbiota influence behavior and mental well-being
By Jennifer Sokolowski, MD, PhD.Gut-microbiome interactionsOn and in our bodies, microbes outnumber our cells by about ten-to-one. Studies have revealed that the microbiome influences neurogenesis, cognition, and...  Read full blog post.

CD11b: Marker for a New Type of B Cell that Participates in Cell-Mediated Immunity
Think B lymphocytes just produce antibodies? Think again! Although, of course, B cells are vital for the humoral immune response, many studies in recent years have begun to uncover antibody-independent actions of B cells: regulating T cells and thus a...  Read full blog post.

Adhesion Receptor Molecule CD11b/c is the Point of Entry for many Infectious Diseases
Pathogenic microorganisms utilize a variety of cell surface receptors to gain entry into host cells and to bypass the natural defense mechanisms. One of the most prominent receptors used in this fashion is the leukocyte adhesion receptor CD11b/c. This...  Read full blog post.

CD11b/CD18 and Neutrophil-Epithelial Interactions as Targets for Anti-Inflammatory Therapies
The beta-2 integrins, a family of four cell surface transmembrane glycoproteins expressed only on leukocytes, include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha subunits (CD11a...  Read full blog post.

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Bioinformatics

Gene Symbol ITGAX
Entrez