CD117/c-kit Antibody (R21-V)

Images

 
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (R21-V) [NBP1-79010] - Membranous CD117 positivity in the classical seminoma. Formalin fixed, paraffin embedded human tissues (4 um sections) stained with anti-CD117 ...read more
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (R21-V) [NBP1-79010] - Membranous CD117 positivity in the classical seminoma. Formalin fixed, paraffin embedded human tissues (4 um sections) stained with anti - CD117.
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (R21-V) [NBP1-79010] - Membranous CD117 positivity in the classical seminoma. Formalin fixed, paraffin embedded human tissues (4 um sections) stained with anti-CD117 ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clone
R21-V
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

CD117/c-kit Antibody (R21-V) Summary

Immunogen
Peptide derived from C-terminal sequence of human CD117. Antibody recognizes the epitope between Ile957 - His973.
Marker
Hematopoietic Stem Cell Marker
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
KIT
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:100 - 1:200
  • Immunohistochemistry-Paraffin 1:100-1:200

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
20mM Tris/HCl (pH 8.0) and 20 mg/ml BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for CD117/c-kit Antibody (R21-V)

  • CD117 antigen
  • CD117
  • ckit
  • c-kit
  • EC 2.7.10
  • EC 2.7.10.1
  • KIT
  • PBT
  • piebald trait
  • Proto-oncogene c-Kit
  • proto-oncogene tyrosine-protein kinase Kit
  • SCF R
  • SCFR
  • SCFRmast/stem cell growth factor receptor
  • soluble KIT variant 1
  • Tyrosine-protein kinase Kit
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

Background

c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Blogs on CD117/c-kit.

Do you see what I see? I c-Kit
The c-Kit (CD117) proto-oncogene is a 145 kD receptor tyrosine kinase family closely related to platelet-derived growth factor receptor (PDGFR). It is a transmembrane receptor and the cellular homolog of the HZ4-feline sarcoma virus transforming gene...  Read full blog post.

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Bioinformatics

Gene Symbol KIT
Uniprot